Results 171 to 180 of about 14,010,421 (310)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Machine learning-driven exploration of therapeutic targets for atrial fibrillation-joint analysis of single-cell and bulk transcriptomes and experimental validation

Frontiers in Cardiovascular Medicine
BackgroundTo explore new therapeutic targets and strategies for atrial fibrillation (AF) by analyzing gene expression profiles of AF patients using machine learning techniques combined with transcriptomic data, and to uncover the potential molecular ...
Yicheng Wang, Yicheng Wang, Yicheng Wang, Hong-Yi Yang, Hong-Yi Yang, Hong-Yi Yang, Zi-Ao Fan, Zi-Ao Fan, Zi-Ao Fan, Jian-Cheng Zhang, Jian-Cheng Zhang, Jian-Cheng Zhang   +11 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Catholic Women's Network, July / August, 1995

, 1995
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core   +1 more source

Quantifying coupling and causality in dynamic bivariate systems: a unified framework for time-domain, spectral, and information-theoretic analysis

Frontiers in Network Physiology
Understanding the underlying dynamics of complex real-world systems, such as neurophysiological and climate systems, requires quantifying the functional interactions between the system units under different scenarios.
Laura Sparacino, Helder Pinto, Chiara Barà, Yuri Antonacci, Riccardo Pernice, Ana Paula Rocha, Luca Faes, Luca Faes   +7 more
doaj   +1 more source

Editorial: Inference, Causality and Control in Networks of Dynamical Systems: Data Science and Modeling Perspectives to Network Physiology With Implications for Artificial Intelligence. [PDF]

Front Physiol, 2022
Bogdan P, Ivanov PC, Pequito S.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Catholic Women's Network, March / April, 1996

, 1996
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core  

Applications of Network Physiology in Neonatology

, 2021
Every year, an estimated 15 million babies are born preterm, that is, before 37 weeks of gestation. This number is rising in all countries and currently represents more than 1 in 10 babies, affecting families all over the world. During the last decades, the survival rate of prematurely born neonates has steadily increased, mainly as a result of medical
openaire   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source