Results 151 to 160 of about 271,086 (294)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Gradients of O-information highlight synergy and redundancy in physiological applications

The study of high order dependencies in complex systems has recently led to the introduction of statistical synergy, a novel quantity corresponding to a form of emergence in which patterns at large scales are not traceable from lower scales.
Sparacino, Laura, Stramaglia, Sebastiano, Scagliarini, Tomas, Faes, Luca, Marinazzo, DanielePP018020009600330000-0002-9803-012231BC56A8-F0EE-11E1-A9DE-61C894A0A6B4   +4 more
core  

From visibility graphs to cognition

Frontiers in Network Physiology
The aim of this study is to discuss the adoption of the popular natural visibility graph method (NVGM) to create complex networks and explore the condition, ignored by early work on this subject, where the dynamical system under analysis is characterized
Sabin Gautam, Paolo Grigolini
doaj   +1 more source

GABAergic cortical network physiology in frontotemporal lobar degeneration. [PDF]

Brain, 2021
Adams NE, Hughes LE, Rouse MA, Phillips HN, Shaw AD, Murley AG, Cope TE, Bevan-Jones WR, Passamonti L, Street D, Holland N, Nesbitt D, Friston K, Rowe JB.   +13 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

ARC/NHMRC Research Network in Genes and Environment in Development

ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals.

core  

Predictive modeling for cervical cancer: existing AI approaches and the emerging role of vaginal microbiome

Frontiers in Network Physiology
Cervical cancer remains a major global health burden, yet current screening tools lack precision in identifying which women with high-risk human papillomavirus (HPV) infection will progress to high-grade lesions or cancer.
Michelle Gomes, Michelle Gomes, Zonglun Li, Zonglun Li, Adeola Olaitan, Aleksandra Gentry-Maharaj   +5 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Editorial: Granger causality and information transfer in physiological systems: basic research and applications

Frontiers in Network Physiology, 2023
Sonia Charleston-Villalobos, Michal Javorka, Luca Faes, Andreas Voss   +3 more
doaj   +1 more source