Results 71 to 80 of about 1,278,074 (287)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Scientific World Journal, 2014 Network connectivity and link quality information are the fundamental requirements of wireless sensor network protocols to perform their desired functionality.
Marjan Radi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Non-collaborative Attackers and How and Where to Defend Flawed Security Protocols (Extended Version)
, 2014 Security protocols are often found to be flawed after their deployment. We present an approach that aims at the neutralization or mitigation of the attacks to flawed protocols: it avoids the complete dismissal of the interested protocol and allows honest
A Armando +13 more
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Bridging All-Photonic and Memory-Based Quantum Repeaters
IEEE Transactions on Quantum EngineeringThe all-photonic quantum repeater scheme based on repeater graph states (RGSs) offers a promising approach for constructing quantum networks without relying on long-coherence-time quantum memories, which remain a significant technological challenge ...
Naphan Benchasattabuse +2 more
doaj +1 more source
NPVT: Network Protocol Validation Testbed for Integrated Space-Terrestrial Network
IEEE Access, 2019 With the development of the terrestrial network and the increase in demand for providing global Internet access, using the integrated space-terrestrial network (ISTN) has attracted significant attention to provide the global Internet service.
Zengyin Yang +3 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A Comprehensive Study on Reactive and Proactive Routing Protocols under different performance Metric
Sukkur IBA Journal of Emerging Technologies, 2019 Mobile Ad-hoc Network (MANET) has recently gained enormous studies attention because of their large potential of reliability and scalability in various fields.
Sadaf Wali +3 more
doaj +1 more source