Results 141 to 150 of about 574,210 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Classification of skin pigmented lesions based on deep residual network

open access: yes, 2019
There are various of skin pigmented lesions with high risk. Melanoma is one of the most dangerous forms of skin cancer. It is one of the important research directions of medical artificial intelligence to carry out classification research of skin ...
Zhou, Rui   +7 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Network Representation of Conducting Regions in 3D Finite Element Description of Electrical Machines

open access: yes, 2007
The paper introduces a network description of conducting regions in electrical machines. Resistance models are considered, where loop equations are equivalent to an edge element formulation (EEM) using electric vector potential T, as well as conductance ...
Sykulski, J.K., Demenko, A.
core  

Increasing the spatial resolution of agricultural land cover maps using a Hopfield neural network

open access: yes, 2003
Land cover class composition of remotely sensed image pixels can be estimated using soft classification techniques increasingly available in many GIS packages.
Tatem, A.J.   +7 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Political Representation of National Minorities: A Case Study of Minority Parties in Serbia [PDF]

open access: yes, 2013
This thesis explores the relationship between descriptive and substantive representation of national minorities. Previous studies have emphasized the importance of descriptive representation and justified the need for affirmative action measures such as ...
Loncar, Jelena
core  

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