Results 151 to 160 of about 574,210 (309)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Detecting erroneous identity links on the web using network metrics

, 2018
In the absence of a central naming authority on the Semantic Web, it is common for different datasets to refer to the same thing by different IRIs. Whenever multiple names are used to denote the same thing, owl:sameAs statements are needed in order to ...
Raad, Joe, Simperl, Elena, Vrandecic, Denny, van Harmelen, Frank, Saïs, Fatiha, Suárez-Figueroa, Mari Carmen, Kaffee, Lucie-Aimee, Celino, Irene, Presutti, Valentina, Sabou, Marta, Pernelle, Nathalie, Bontcheva, Kalina, Beek, Wouter   +12 more
core   +1 more source

Network Comparison with Interpretable Contrastive Network Representation Learning. [PDF]

J Data Sci Stat Vis, 2022
Fujiwara T, Zhao J, Chen F, Yu Y, Ma KL.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Prediction of potential small molecule-miRNA associations based on heterogeneous network representation learning. [PDF]

Front Genet, 2022
Li J, Lin H, Wang Y, Li Z, Wu B.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

statnet: Software Tools for the Representation, Visualization, Analysis and Simulation of Network Data

statnet is a suite of software packages for statistical network analysis. The packages implement recent advances in network modeling based on exponential-family random graph models (ERGM).
David R. Hunter, Steven M. Goodreau, Martina Morris, Carter T. Butts, Mark S. Handcock   +4 more
core  

General framework for E(3)-equivariant neural network representation of density functional theory Hamiltonian. [PDF]

Nat Commun, 2023
Gong X, Li H, Zou N, Xu R, Duan W, Xu Y.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Multi-view heterogeneous molecular network representation learning for protein-protein interaction prediction. [PDF]

BMC Bioinformatics, 2022
Su XR, Hu L, You ZH, Hu PW, Zhao BW.
europepmc   +1 more source