Results 151 to 160 of about 32,401,733 (254)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Network science reveals the structure and lasting impact of the Roman road system. [PDF]

Nat Commun
Pažout A, Brughmans T, de Soto P, Mazzamurro M, Coto-Sarmiento M, Filet C, Herrera Malatesta E, Nielsen ML, Ølgaard GE, Vahlstrup PB.   +9 more
europepmc   +1 more source

Catholic Women's Network, November / December, 1995

, 1995
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Decoding the evolution of melodic and harmonic structure of Western music through the lens of network science. [PDF]

Sci Rep
Di Marco N, Loru E, Galeazzi A, Cinelli M, Quattrociocchi W.   +4 more
europepmc   +1 more source

Care4Rare Canada: Outcomes from a decade of network science for rare disease gene discovery. [PDF]

Am J Hum Genet, 2022
Boycott KM, Hartley T, Kernohan KD, Dyment DA, Howley H, Innes AM, Bernier FP, Brudno M, Care4Rare Canada Consortium.   +8 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Learning from sanctioned government suppliers: a machine learning and network science approach to detecting fraud and corruption in Mexico. [PDF]

Sci Rep
Medina-Hernández M, Kertész J, Fazekas M.   +2 more
europepmc   +1 more source

Towards Predictive Synthesis of Inorganic Materials Using Network Science. [PDF]

Front Chem, 2021
Aziz A, Carrasco J.
europepmc   +1 more source

Catholic Women's Network, January / February, 1996

, 1996
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core