Results 81 to 90 of about 151,952 (268)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Object Detection by Contour Segment Networks [PDF]
, 2006 We propose a method for object detection in cluttered real images, given a single hand-drawn example as model. The image edges are partitioned into contour segments and organized in an image representation which encodes their interconnections: the Contour Segment Network.
Ferrari, V. +2 more
openaire +3 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Development of microcatheter tube extrusion angle estimation system using convolutional neural network segmentation. [PDF]
Sci Rep, 2023 Jeong SH, Lee SH, Won HI.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Joint Optic Disc and Optic Cup Segmentation Based on Adversarial Learning and Guidance Mechanism [PDF]
Jisuanji gongchengAccurate segmentation of the Optic Disc(OD) and Optic Cup(OC) effectively assists in diagnosing and monitoring glaucoma, thereby improving treatment outcomes.
MA Xiaoyue, CHEN Yuanyuan
doaj +1 more source
Analysis of Convolutional Neural Network Segmentation Algorithm of Adenomyoma. [PDF]
Comput Intell Neurosci, 2022 Jin Y, Huang W, Qu Q.
europepmc +1 more source
Trusting Semantic Segmentation Networks
CoRRSemantic segmentation has become an important task in computer vision with the growth of self-driving cars, medical image segmentation, etc. Although current models provide excellent results, they are still far from perfect and while there has been significant work in trying to improve the performance, both with respect to accuracy and speed of ...
Samik Some, Vinay P. Namboodiri
openaire +2 more sources