Results 31 to 40 of about 7,621 (201)

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Interpretability and Representability of Commutative Algebra, Algebraic Topology, and Topological Spectral Theory for Real‐World Data

Advanced Intelligent Discovery, EarlyView.
This article investigates how persistent homology, persistent Laplacians, and persistent commutative algebra reveal complementary geometric, topological, and algebraic invariants or signatures of real‐world data. By analyzing shapes, synthetic complexes, fullerenes, and biomolecules, the article shows how these mathematical frameworks enhance ...
Yiming Ren, Guo‐Wei Wei
wiley   +1 more source

Multi-Objective Optimization for Economic and Environmental Sustainability in Apparel E-commerce Reverse Logistics [PDF]

International Journal of Mathematical, Engineering and Management Sciences
In the realm of supply chains, the necessity of a robust reverse logistics network is paramount. While substantial efforts have been directed towards enhancing forward logistics, the domain of reverse logistics remains underdeveloped.
Nikhil Sharma, Chirag Saraswat, Jeetesh Sharma, Murari Lal Mittal, Arvind Keprate   +4 more
doaj   +1 more source

Parameter Identification of Pilot Model and Stability Analysis of Human-in-Loop Image Seeker

Aerospace, 2023
In the human-in-loop (HIL) guidance mode, a pilot quickly identifies and flexibly locks on to a target through a real-time image signal transmitted by the aircraft. Then, the line-of-sight (LOS) angle error in the viewing field is tracked and compensated
Yi Zhang, Tao Li, Yanning Li, Gen Wang
doaj   +1 more source

On the simplex algorithm for networks and generalized networks [PDF]

, 1985
The paper deals with the generalized network flow problem (GNFP), which is a minimum cost linear programming problem, where the coefficient matrix contains at most two nonzero entries of opposite sign, in each column. Also lower and upper bounds on the variables are present.
openaire   +3 more sources

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Simulation and Evaluation of Network Simplex Algorithm and its Extensions for Vehicle Scheduling Problems in Ports

International Journal of Maritime Technology, 2019
The Minimum Cost Flow (MCF) problem is a well-known problem in the area of network optimisation. To tackle this problem, Network Simplex Algorithm (NSA) is the fastest solution method. NSA has three extensions, namely Network Simplex plus Algorithm (NSA+)
Hassan Rashidi
doaj  

Short-Term Road Speed Forecasting Based on Hybrid RBF Neural Network With the Aid of Fuzzy System-Based Techniques in Urban Traffic Flow

IEEE Access, 2020
With the rapid economic development, urban areas are seeing more and more vehicles, leading to frequent urban traffic congestion. To solve this problem, the forecasting of traffic parameters is essential, in which, road operating speed (hereinafter ...
Chun Ai, Lijun Jia, Mei Hong, Chao Zhang
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Inversion of Rayleigh Wave Dispersion Curve Extracting from Ambient Noise Based on DNN Architecture

Applied Sciences, 2023
The inversion of the Rayleigh wave dispersion curve is a crucial step in obtaining the shear wave velocity (VS) of near-surface structures. Due to the characteristics of being ill-posed and nonlinear, the existing inversion methods presented low ...
Qingsheng Meng, Yuhong Chen, Fei Sha, Tao Liu   +3 more
doaj   +1 more source