Results 71 to 80 of about 914 (259)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A Proposed Algorithm for Steganography

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
Steganography is an important class of security which is widely used in computer and network security nowadays. In this research, a new proposed algorithm was introduced with a new concept of dealing with steganography as an algorithmic secret key ...
A.O. Ibadi, O. Z. Akif
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Network Steganography in the DNS Protocol

International Journal of Electronics and Telecommunications, 2016
Abstract This paper presents possibility of using of the DNS (Domain Name System) protocol for creating a simplex communication channel between a malware-infected computer with a compromised DNS server. The proposed channel can be used to steal data or confidential enterprise information secretly.
Michał Drzymała, Krzysztof Szczypiorski, Marek Łukasz Urbański   +2 more
openaire   +1 more source

AUDIO CRYPTANALYSIS- AN APPLICATION OF SYMMETRIC KEY CRYPTOGRAPHY AND AUDIO STEGANOGRAPHY

ICTACT Journal on Communication Technology, 2016
In the recent trend of network and technology, “Cryptography” and “Steganography” have emerged out as the essential elements of providing network security. Although Cryptography plays a major role in the fabrication and modification of the secret message
Smita Paira, Sourabh Chandra
doaj  

Adaptive Image Steganography Algorithm Based on Deep Reinforcement Learning [PDF]

Jisuanji gongcheng
This study proposes an Adaptive Image Steganography Algorithm based on Deep Reinforcement Learning (AISA-DRL) to realize a balance among lightweight steganography, optimal embedding positioning, and high hidden outputs. A lightweight secure steganography
Qing QIAN, Yong LONG, Zhongyuan JIANG, Chunhong DUAN, Hong WANG
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Hiding image into image with hybrid attention mechanism based on GANs

IET Image Processing
Image steganography is the art of concealing secret information within images to prevent detection. In deep‐learning‐based image steganography, a common practice is to fuse the secret image with the cover image to directly generate the stego image ...
Yuling Zhu, Yunyun Dong, Bingbing Song, Shaowen Yao   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source