Results 101 to 110 of about 15,116,931 (337)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Pure Relationality as a Sociological Theory of Communication

Frontiers in Sociology, 2018
In order to explain the success of populist politicians use of social media, we need to subtract the social from relationality and separate social relationships from network theory applications.
Sam Whimster
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Efficient marine predators algorithm for solving multidimensional complex functions and real-world engineering design problems

工程科学学报
As optimization problems grow increasingly complex, characterized by their intricate difficulty, larger-scale, and diverse constraints, swarm intelligence optimization algorithms have emerged as an effective solution for addressing these multifaceted ...
Jingsen LIU, Wenkai FAN, Lin SUN, Huan ZHOU   +3 more
doaj   +1 more source

Essays on Applied Network Theory. [PDF]

Network economics is a fast growing area of study, with a lot of potential for addressing a wide variety of socio-economic phenomena. Networks literally permeate our social and economic lives. The unemployed find jobs using the information and assistance
TETERYATNIKOVA, Mariya, TETERYATNIKOVA, Mariya, TETERYATNIKOVA, Mariya, TETERYATNIKOVA, Mariya, TETERYATNIKOVA, Mariya   +4 more
core  

Research on Evolutionary Mechanism of Agile Supply Chain Network via Complex Network Theory

, 2016
The paper establishes the evolutionary mechanism model of agile supply chain network by means of complex network theory which can be used to describe the growth process of the agile supply chain network and analyze the complexity of the agile supply ...
N. Xu, Jia-Bao Liu, D. Li, Jun Wang
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A Cross-Layer Approach to Analyzing Energy Consumption and Lifetime of a Wireless Sensor Node

Journal of Sensor and Actuator Networks
Several wireless communication technologies, including Wireless Sensor Networks (WSNs), are essential for Internet of Things (IoT) applications. WSNs employ a layered framework to govern data exchanges between sender and recipient, which facilitates the ...
Fernando Ojeda, Diego Mendez, Arturo Fajardo, Maximilian Gottfried Becker, Frank Ellinger   +4 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Improving audit functions of supreme audit institutions to promote sustainable development

Apstract: Applied Studies in Agribusiness and Commerce, 2012
In this paper, we demonstrate and analyze the substance of the added value effect of a Supreme Audit Institution (SAI), focusing on sustainable development issues.We intend to answer such questions as: how could a SAI respond to global and local ...
Sándor Nagy, József Gál, Antal Véha   +2 more
doaj   +1 more source