Results 61 to 70 of about 11,592 (210)

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Configuration and innovation related network topology

Journal of Innovation & Knowledge, 2016
Network topologies attract much theoretical attention in recent studies. Researchers adopt network topology models and assert that specific type of network topology improves product and process innovation.
Ela Ozkan-Canbolat, Aydin Beraha
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Network Topology Availability Analysis [PDF]

Telfor Journal, 2011
In this paper the availabilities of some network topologies are analyzed and calculated. Software based on exact All-terminal Graph reduction Algorithm is developed and applied. Results, conclusions and solutions are presented, demonstrated and discussed.
N. Krajnovic, D. Mijatovic, M. Cabarkapa
doaj  

Network Topology Inference Using Higher-Order Statistical Characteristics of End-to-End Measured Delays

IEEE Access, 2020
Network topology is important information for many network control and management applications. Network tomography infers network topology from end-to-end measured packet delays or losses, which is more feasible than internal cooperation-based methods ...
Gaolei Fei, Jian Ye, Sheng Wen, Guangmin Hu   +3 more
doaj   +1 more source

Modeling Networks with Dynamic Topologies [PDF]

ORSA Journal on Computing, 1989
Dynamic hierarchical networks represent an architectural strategy for employing adaptive behavior in applications sensitive to highly variable external demands or uncertain internal conditions. The characteristics of such architectures are described, and the significance of adaptive capability is discussed.
openaire   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Topology Dynamics in a P2PTV Network [PDF]

, 2009
In recent years, a number of commercial peer-to-peer TV (P2PTV) applications have been launched. Yet, their mechanisms and characteristics are unknown. In this paper, we study SopCast, a typical proprietary P2PTV system. Treating SopCast as a black box, we perform a set of experiments that are suitable to analyze SopCast in depth.
Tang, S. (author), Lu, Y. (author), Martín Hernández, J. (author), Kuipers, F.A. (author), Van Mieghem, P. (author)   +4 more
openaire   +2 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source