Results 91 to 100 of about 271,920 (286)
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The vertical integration of ATM switches has stymied the deployment of innovative signaling and service technologies on ATM networks. This panel will discuss current proposals for realizing open signaling and service creation platforms that are inspired by established models of network management.
openaire +1 more source
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Stabilization by controller networks
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Shinsaku Izumi +2 more
openaire +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Mask R-CNN-Based Detection and Segmentation for Pulmonary Nodule 3D Visualization Diagnosis
3D visualization diagnosis for pulmonary nodule detection and segmentation is becoming a promising topic in the field of surgical researches and applications.
Linqin Cai +3 more
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Driven by the importance of energy consumption in system-on-chip design as an evaluation factor, this paper presents a design methodology at the system level to optimize power consumption on ARM-based architecture for real-time video processing.
Lilia Kechiche +2 more
doaj +1 more source
Node-Identification-Based Secure Time Synchronization in Industrial Wireless Sensor Networks
Time synchronization is critical for wireless sensors networks in industrial automation, e.g., event detection and process control of industrial plants and equipment need a common time reference.
Zhaowei Wang +4 more
doaj +1 more source

