Results 51 to 60 of about 116,230 (268)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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AI may help to predict thyroid nodule malignancy based on radiomics features from [18F]FDG PET/CT
EJNMMI ResearchBackground The number of thyroid cancer diagnoses has been increasing for several decades, with a significant part of cases being detected incidentally (thyroid incidentaloma, TI) by imaging studies performed for reasons other than thyroid disease ...
Krystian Ślusarz +10 more
doaj +1 more source
PulmonologyIntroduction and objectives The study examines how hypoxaemia in obstructive sleep apnoea (OSA) relates to cancer. It focuses on CD25, an immune-checkpoint, analyzing its levels in OSA patients with and without cancer to assess whether CD25 could serve ...
Elena Díaz-García +31 more
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Future Internet, 2019 The presented work is a result of extended research and analysis on timing methods precision, their efficiency in different virtual environments and the impact of timing precision on the performance of high-speed networks applications.
Veronika Kirova +6 more
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Semantic IoT Service Communication—Impedance Matching Between Service Goal and Event Routing
International Journal of Distributed Sensor NetworksIn IoT (Internet of Things) applications, there are many kinds of event flows. Without converging these flows based on their semantics, it is difficult to establish ultrascale-connected IoT service systems.
Yang Zhang, Bo Cheng, Junliang Chen
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Marketing fortification of business through crowdsourcing and social responsibility: focus on South African SMEs [PDF]
Environmental Economics, 2017 This paper investigates networking and related activities for marketing performance of small and medium enterprises (SMEs) for the sustainable development and the preservation of the environment. These SMEs have limited business skills and knowledge, and
Eunice Lebogang Sesale +1 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Human Behavior and Emerging TechnologiesDemographic aging presents new challenges and highlights the growing need for smart healthcare applications tailored to older adults. This paper presents the assessment of a mobile health application designed to facilitate the communication between ...
Agnese Augello +5 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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