Results 61 to 70 of about 1,481,628 (268)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Improvement of earthquake and tsunami early warning service capabilities in Japan
地震科学进展In recent years, in order to improve the intelligent level of earthquake prevention and disaster reduction, the Japan Meteorological Agency has continuously improved the functions of the earthquake phenomena observation system (EPOS) and the intelligent ...
Enhui Yan +5 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
地震科学进展According to the Japan Earthquake Disaster Prevention Measures Act, the Headquarters for Earthquake Research Promotion of Japan summarized, adjusted and published the proposed estimates for major funding applications for earthquake investigation and ...
Haiyun Long +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Rapid report of source characteristics of 2025 MS6.8 Dingri, Xizang earthquake sequence
Earth and Planetary PhysicsCharacteristics of the main shock and aftershocks of the Dingri MS6.8 earthquake in the Xizang Autonomous region were determined by the double-difference location method using phase reports from Jan. 7 to Jan. 16, 2025.
Wen Yang +8 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Dizhen xuebao, 2019 预测效果的科学评价是预测学科必须要解决的问题，对地震预测效果的评价一般分为两种，一种是对单次预测成败的评判，另一种是对方法或手段多次预测效果的统计评分。本文提出了针对单次有震预测是否准确的定量评价方法，即地震预测准确性A值评分法。针对我国地震预测现状，本文约定了准确性评分由预测与实际地震的对应情况（简称“对应度” ）和时、空、强预测窗口的精确程度（简称“精确度” ）综合决定，同时，还给出了对应度的计算方法和精确度的评价标准。通过对四川省地震局2013年2月上报的短期预测意见进行试算 ...
Wei Yan +6 more
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