Results 81 to 90 of about 1,481,628 (268)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Thoughts and suggestions on upgrading and replacing earthquake monitoring networks and the design in the disaster prevention project

地震科学进展
This article has summarized the shortcomings and deficiencies in the construction and operation of the earthquake monitoring station network of China, analyzes the trend of modernization development of the monitoring station network, and proposes ...
Dan Yu, Yu Li, Chunguo Liu, Guangbao Du, Rui Zhang   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Determination of focal mechanism solutions of the earthquakes with M≥4.0 occurred in the mainland of China during July to December 2024

地震科学进展
In this paper，the regional full waveform inversion using the broadband waveforms recorded by China Seismic Network were conducted, and the focal mechanism solutions of the 38 earthquakes with M≥4.0 occurred in the mainland of China during July to ...
Shanshan Liang, Liye Zou, Yanqiong Liu, Xumao Li, Xiao Ren   +4 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Networking Outside the Networks

, 2009
Due to the recent unfortunate events, for example, the ability to monitor and control the messages and data transferred in the Internet has gained attention. However, there also exist methods for networking beyond any control. Smart, hand-held mobile devices with support for communication technologies such as the WLAN allow spontaneous, ad-hoc networks
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Energy Efficient AR/VR Edge Processing: Architecture and Optimization

IEEE Access
This article introduces a server-centric cellular Passive Optical Network (C-PON) architecture to support the deployment of Augmented Reality (AR)/ Virtual Reality (VR) event viewing applications in edge data centers.
Azza E. A. Eltraify, Randa A. Thabit, Opeyemi O. Ajibola, Wafaa B. M. Fadlelmula, Ahmed A. M. Hassan, Ahrar N. S. Hamad, Abdelrahman S. Elgamal, Walter Z. Ncube, Harith S. Ibrahim, Mariam Elmirghani, Sanaa Hamid Mohamed, Louise Krug, Greg Mcsorley, Jaafar M. H. Elmirghani   +13 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source