Results 71 to 80 of about 6,198,210 (289)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Neural simplex architecture

, 2020
We present the Neural Simplex Architecture (NSA), a new approach to runtime assurance that provides safety guarantees for neural controllers (obtained e.g. using reinforcement learning) of autonomous and other complex systems without unduly sacri cing
Jansen, Nils, Smolka, Scott A., Grosu, Radu, Paoletti, Nicola, Stoller, Scott D., Phan, Dung   +5 more
core   +4 more sources

Learning a Unified Latent Space for NAS: Toward Leveraging Structural and Symbolic Information

IEEE Access, 2022
Automatically designing neural architectures, i.e., NAS (Neural Architecture Search), is a promising path in machine learning. However, the main challenge for NAS algorithms is to reduce the considerable elapsed time to evaluate a proposed network.
Saeedeh Eslami, Reza Monsefi, Mohammad Akbari   +2 more
doaj   +1 more source

BANANAS: Bayesian Optimization with Neural Architectures for Neural Architecture Search

Proceedings of the AAAI Conference on Artificial Intelligence, 2021
Over the past half-decade, many methods have been considered for neural architecture search (NAS). Bayesian optimization (BO), which has long had success in hyperparameter optimization, has recently emerged as a very promising strategy for NAS when it is coupled with a neural predictor.
Colin White, Willie Neiswanger, Yash Savani   +2 more
openaire   +2 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Interleaving multi-task neural architecture search

npj Artificial Intelligence
Multi-task neural architecture search (MTNAS), which searches for a shared architecture for multiple tasks, has been broadly investigated. In these methods, multiple tasks are learned simultaneously by minimizing the weighted sum of their losses.
Hao Ban, Li Zhang, Pengtao Xie
doaj   +1 more source

Training-free neural architecture search: A review

ICT Express
The goal of neural architecture search (NAS) is to either downsize the neural architecture and model of a deep neural network (DNN), adjust a neural architecture to improve its end result, or even speed up the whole training process.
Meng-Ting Wu, Chun-Wei Tsai
doaj   +1 more source

Evaluating the Search Phase of Neural Architecture Search

CoRR, 2019
We find that random policy in NAS works amazingly well and propose an evaluation framework to have a fair comparison. Adding additional results on standard CNN search space used for weight sharing and NASBench-101.
Kaicheng Yu, Christian Sciuto, Martin Jaggi, Claudiu Musat, Mathieu Salzmann   +4 more
openaire   +4 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source