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Phylogeny of a neural cell adhesion molecule
Developmental Biology, 1985The phylogeny of adhesion among cells derived from neural tissue has been examined using a combination of functional and immunological analyses. The presence of the neural cell adhesion molecule (NCAM) was evaluated with respect to NCAM-specific antigenic determinants attached to a polypeptide chain with appropriate electrophoretic properties. By these
A K, Hall, U, Rutishauser
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Heterogeneity of Soluble Neural Cell Adhesion Molecule
Journal of Neurochemistry, 1989Abstract: Soluble neural cell adhesion molecule (NCAM) from rat brain neuronal cell culture media consists predominantly of a polypeptide of Mr∼ 115,000. Minor amounts of a polypeptide of Mr∼ 180,000 and two inconsistently appearing components of Mr 160,000 and 145,000 are also observed.
O, Nybroe, D, Linnemann, E, Bock
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Cell Adhesion Molecules in Neural Histogenesis
Annual Review of Physiology, 1986Aside from evolutionary change itself, there are three main sources of variabil ity in neural networks: the somatic developmental sequence, which is responsi ble for network formation and neuroanatomy; the chemical and structural variation at synapses (particularly that related to neurotransmitters and chan nels); and the electrical variation that ...
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Neural GPI anchored cell adhesion molecules
Frontiers in Bioscience, 2003When first identified, neural cell adhesion molecules (neural CAMs) were thought to act simply by providing cell surfaces with differential adhesion properties. In the decades following the identification of the first neural CAMs, it has been realized that these proteins are actually involved in very complex processes such as axon guidance, neuronal ...
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Neural cell adhesion molecule (CD56)‐positive B‐cell lymphoma
European Journal of Haematology, 2007AbstractExpression of neural cell‐adhesion molecule CD56 is a rare event in B‐cell lymphoma. We described four cases of CD56‐positive B‐cell lymphoma, including follicular lymphoma and diffuse large B‐cell lymphoma. These lymphoma cells expressed CD10 and bcl‐6, which suggests germinal center‐stage phenotype.
Yasushi, Isobe +6 more
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Targeting the neural cell adhesion molecule in cancer
Cancer Letters, 2007NCAM is a tumour associated antigen expressed on small cell lung cancer, neuroblastoma, rhabdomyosarkoma, brain tumours, multiple myelomas and acute myeloid leukaemia. Constant and strong expression of NCAM is a prerequisite for the development of antibody-based immunotherapies.
Markus, Jensen, Frank, Berthold
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Intracellular Signaling by the Neural Cell Adhesion Molecule
Neurochemical Research, 2003Cell adhesion molecules are known to play far more complex roles than mechanically attaching one cell to an adjacent cell or to components of the extracellular matrix. Thus, important roles for cell adhesion molecules in the regulation of intracellular signaling pathways have been revealed.
Povlsen, Gro K. +3 more
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The neural cell adhesion molecule and synaptic plasticity
Journal of Neurobiology, 1995AbstractHighly stereotyped patterns of neuronal connections are laid down during the development of the nervous system via a range of activity independent and activity dependent mechanisms. Whereas the coarse hard‐wiring of the nervous system appears to rely on molecular recognition events between the neuron, its pathway, and its target, the ...
P, Doherty, M S, Fazeli, F S, Walsh
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Neural cell adhesion molecule expression in thyroid cancer
Oncology Reports, 1996Neural cell adhesion molecule (NCAM) is an integral membrane glycoprotein that participates in cell-cell interactions. We examined the expression of neural cell adhesion molecule (NCAM) by immunohistochemistry in 65 cases of thyroid disease. In the majority of thyroid tumors, NCAM expression was detected in tumor cells.
Y, Miyajima +6 more
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