A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls+9 more
wiley +1 more source
Transport properties in network models with perfectly conducting channels [PDF]
We study the transport properties of disordered electron systems that contain perfectly conducting channels. Two quantum network models that belong to different universality classes, unitary and symplectic, are simulated numerically. The perfectly conducting channel in the unitary class can be realized in zigzag graphene nano-ribbons and that in the ...
arxiv +1 more source
Conducting the Neural Symphony of Memory Replay
Hippocampal sharp-wave ripple oscillations and sequence replay events are important for memory. Ramirez-Villegas et al. present a model that dissects cellular mechanisms of SWR generation in the CA3-CA1 circuit, and explains the network features of slow-gamma coordination and sequence replay.
Wenbo Tang, Shantanu P. Jadhav
openaire +3 more sources
Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers+7 more
wiley +1 more source
Spiking Neural P Systems with Membrane Potentials, Inhibitory Rules, and Anti-Spikes
Spiking neural P systems (SN P systems for short) realize the high abstraction and simulation of the working mechanism of the human brain, and adopts spikes for information encoding and processing, which are regarded as one of the third-generation neural
Yuping Liu, Yuzhen Zhao
doaj +1 more source
Modeling sparse connectivity between underlying brain sources for EEG/MEG [PDF]
We propose a novel technique to assess functional brain connectivity in EEG/MEG signals. Our method, called Sparsely-Connected Sources Analysis (SCSA), can overcome the problem of volume conduction by modeling neural data innovatively with the following ...
Haufe, Stefan+4 more
core +1 more source
Evolving conductive polymer neural networks on wetware [PDF]
Neural networks in brain are structured in a 3-D space, and the networks are evolved through development and learning, whereas 2-D crossbars have essentially been optimized for fully-connected neural network, which results in significant increase of unused memristors.
Tetsuya Asai+7 more
openaire +3 more sources
The anterior nucleus of the thalamus plays a role in the epileptic network
Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan+9 more
wiley +1 more source
Oligodendrocyte-mediated myelin plasticity and its role in neural synchronization
Temporal synchrony of signals arriving from different neurons or brain regions is essential for proper neural processing. Nevertheless, it is not well understood how such synchrony is achieved and maintained in a complex network of time-delayed neural ...
Sinisa Pajevic+3 more
doaj +1 more source
Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array
Myelinated fibers are specialized neurological structures used for conducting action potentials quickly and reliably, thus assisting neural functions.
Kenta Shimba+5 more
doaj +1 more source