Results 81 to 90 of about 2,093,786 (309)

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

open access: yesMolecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza   +5 more
wiley   +1 more source

Elastomeric and soft conducting microwires for implantable neural interfaces [PDF]

open access: yesSoft Matter, 2015
Novel ultra-soft neural microwire electrodes demonstrated excellent biocompatibility, high surface charge capacity, large electrochemical surface area, and sufficient electrical properties for recording single-unit activity from rodent visual cortex.
Jenna Hanner   +10 more
openaire   +3 more sources

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

open access: yesMolecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun   +5 more
wiley   +1 more source

Monitorización intraoperatoria de los nervios laríngeos superior e inferior en cirugía de tiroides y paratiroides Intraoperative monitoring of superior and inferior laryngeal nerves during thyroid and parathyroid surgery

open access: yesRevista Colombiana de Cirugía, 2012
La cirugía endocrina, y particularmente la cirugía de tiroides y paratiroides, ha experimentado múltiples cambios desde la década de los años 30 cuando se evidenció la disminución de las parálisis de las cuerdas vocales con la identificación visual del ...
Juan Pablo Dueñas, Carlos Simón Duque
doaj  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Myelin-induced gain control in nonlinear neural networks

open access: yesCommunications Physics
Myelin surrounds axonal membranes to increase the conduction velocity of nerve impulses and thus reduce communication delays in neural signaling. Changes in myelination alter the distribution of delays in neural circuits, but the implications for their ...
Jérémie Lefebvre   +3 more
doaj   +1 more source

Recent Approaches on Signal Transduction and Transmission in Acupuncture: A Biophysical Overview for Medical Sciences

open access: yesJournal of Acupuncture & Meridian Studies, 2020
Acupuncture is one of the areas among the alternative therapies that arise high curiosity in the biomedical scientific community. It is particularly popular for treatment of chronic diseases and addictions.
Lígia Rebelo Gomes, Pedro Leão
doaj  

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

open access: yesFEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal   +2 more
wiley   +1 more source

Effects of Fish Oil Supplementation during the Suckling Period on Auditory Neural Conduction in n-3 Fatty Acid-Deficient Rat Pups [PDF]

open access: yesIranian Journal of Otorhinolaryngology, 2014
Introduction: Omega 3 fatty acid especially in the form of fish oil, has structural and biological role in the body's various systems especially nervous system. Numerous studies have tried to research about it.
vida rahimi   +4 more
doaj   +2 more sources

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