Results 141 to 150 of about 446,619 (318)

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

Model of autism: increased ratio of excitation/inhibition in key neural systems [PDF]

, 2003
John L.R. Rubenstein, Michael M. Merzenich   +1 more
openalex   +1 more source

Understanding Inhibition Through Maximally Tense Images [PDF]

arXiv
We address the functional role of 'feature inhibition' in vision models; that is, what are the mechanisms by which a neural network ensures images do not express a given feature? We observe that standard interpretability tools in the literature are not immediately suited to the inhibitory case, given the asymmetry introduced by the ReLU activation ...
arxiv  

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Excitation-inhibition balance controls information encoding in neural populations [PDF]

arXiv
Understanding how the complex connectivity structure of the brain shapes its information-processing capabilities is a long-standing question. By focusing on a paradigmatic architecture, we study how the neural activity of excitatory and inhibitory populations encodes information on external signals.
arxiv  

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Conducting Polymer Microelectrode Arrays for Simultaneous Electrophysiology and Advanced Brain Imaging

Advanced Functional Materials, EarlyView.
A flexible micro‐electrocorticography array with PEDOT:SS electrodes is shown to be compatible with ultra‐high magnetic field MRI up to 9.4 T. Multimodal brain monitoring is demonstrated by performing simultaneous blood oxygen level‐dependent functional MRI in parallel with electrophysiology.
Sagnik Middya, Alejandro Carnicer‐Lombarte, Stephen Sawiak, Sam Hilton, Vincenzo F Curto, Damiano G Barone, Gabriele S Kaminski Schierle, George G Malliaras   +7 more
wiley   +1 more source

Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations

Advanced Functional Materials, EarlyView.
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou, Lauren Brown, Christopher M. Madl   +2 more
wiley   +1 more source

Proteasome Inhibition Alters Neural Mitochondrial Homeostasis and Mitochondria Turnover [PDF]

, 2004
Patrick G. Sullivan, Natasa Dragicevic, Jian-Hong Deng, Yidong Bai, Edgardo Dimayuga, Qunxing Ding, Qinghua Chen, Annadora J. Bruce‐Keller, Jeffrey N. Keller   +8 more
openalex   +1 more source

Identifying the Role of Block Length in Neural Heat Block to Reduce Temperatures During Infrared Neural Inhibition. [PDF]

Lasers Surg Med, 2020
Ford JB, Ganguly M, Poorman ME, Grissom WA, Jenkins MW, Chiel HJ, Jansen ED.   +6 more
europepmc   +1 more source