Results 121 to 130 of about 2,658,546 (298)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Robust Local Cluster Neural Networks (ESANN) [PDF]

, 2006
Eickhoff R, Sitte J, Rückert U. Robust Local Cluster Neural Networks (ESANN). In: Proceedings of the 14th European Symposium on Artificial Neural Networks (ESANN).
Eickhoff, Ralf, Rueckert, Ulrich, Sitte, Joaquin, Rückert, Ulrich   +3 more
core  

Inhibition ability of food cues between successful and unsuccessful restrained eaters: a two-choice oddball task.

PLoS ONE, 2015
BackgroundPrevious studies have presented mixed findings on the inhibition ability in restrained eaters (REs) due to the limited amount of neural evidence and limitations of behavioral measures.
Fanchang Kong, Yan Zhang, Hong Chen
doaj   +1 more source

Cellular mechanisms underlying state-dependent neural inhibition with magnetic stimulation. [PDF]

Sci Rep, 2022
Ye H, Chen V, Hendee J.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

ROCK inhibition enhances neurite outgrowth in neural stem cells by upregulating YAP expression in vitro

Neural Regeneration Research, 2016
Spontaneous axonal regeneration of neurons does not occur after spinal cord injury because of inhibition by myelin and other inhibitory factors. Studies have demonstrated that blocking the Rho/Rho-kinase (ROCK) pathway can promote neurite outgrowth in ...
Xu-feng Jia, Fei Ye, Yan-bo Wang, Da-xiong Feng   +3 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

An Asymmetric Inhibition Model of Hemispheric Differences in Emotional Processing [PDF]

, 2014
Two relatively independent lines of research have addressed the role of the prefrontal cortex in emotional processing. The first examines hemispheric asymmetries in frontal function; the second focuses on prefrontal interactions between cognition and ...
Grimshaw, Gina M, David eCarmel, David Carmel, Gina M Grimshaw, Gina M. Grimshaw, Carmel, David   +5 more
core   +1 more source

Enriched Environment Prevents Surgery-Induced Persistent Neural Inhibition and Cognitive Dysfunction. [PDF]

Front Aging Neurosci, 2021
Yang S, Zhang S, Tang W, Fang S, Zhang H, Zheng J, Liu X, Zhang Y, Zhao L, Huang L, Li B.   +10 more
europepmc   +1 more source

Inhibited Softmax for Uncertainty Estimation in Neural Networks

CoRR, 2018
We present a new method for uncertainty estimation and out-of-distribution detection in neural networks with softmax output. We extend softmax layer with an additional constant input. The corresponding additional output is able to represent the uncertainty of the network.
Marcin Mozejko, Mateusz Susik, Rafal Karczewski   +2 more
openaire   +3 more sources