Results 101 to 110 of about 2,658,546 (298)

Alcohol impacts an fMRI marker of neural inhibition in humans and rodents

NeuroImage
Inhibitory neuronal activity is a key regulator of brain function and is implicated in numerous developmental and psychiatric disorders. However, measuring inhibition in vivo remains a challenge.
Monami Nishio, Xinyi Wang, Eli J. Cornblath, Sung-Ho Lee, Yen-Yu Ian Shih, Nicola Palomero-Gallagher, Michael J. Arcaro, David M. Lydon-Staley, Allyson P. Mackey   +8 more
doaj   +1 more source

Neural development of selective attention and response inhibition

NeuroImage, 2003
Brain activation differences between 12 children (9- to 12-year-olds) and 12 adults (20- to 30-year-olds) were examined on two cognitive tasks during functional magnetic resonance imaging (fMRI). Spatial selective attention was measured with the visual search for a conjunction target (red triangle) in a field of distracters and response inhibition was ...
James R. Booth, Douglas D. Burman, Joel R. Meyer, Lei Zhang, Barbara L. Trommer, Nicholas D. Davenport, Wei Li, Todd B. Parrish, Darren R. Gitelman, M.-Marsel Mesulam   +9 more
openaire   +3 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Stimulation of glia reveals modulation of mammalian spinal motor networks by adenosine [PDF]

, 2015
This work was funded by the Wellcome Trust Institutional Strategic Support Fund for University of St. Andrews.Despite considerable evidence that glia can release modulators to influence the excitability of neighbouring neurons, the importance of ...
Miles, Gareth B., David Acton, Acton David, Miles Gareth B., Acton, David, Gareth B Miles   +5 more
core   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Global Neural Activities Changes under Human Inhibitory Control Using Translational Scenario

Brain Sciences, 2020
This study presents a new approach to exploring human inhibition in a realistic scenario. In previous inhibition studies, the stimulus design of go/no-go task generally used a simple symbol for the go and stop signals.
Rupesh Kumar Chikara, Li-Wei Ko
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pre-integration lateral inhibition enhances unsupervised learning [PDF]

, 2002
A large and influential class of neural network architectures use post-integration lateral inhibition as a mechanism for competition. We argue that these algorithms are computationally deficient in that they fail to generate, or learn, appropriate ...
Spratling, Michael, Spratling, M. W., Johnson, M, Johnson, M. H.   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source