Results 81 to 90 of about 2,658,546 (298)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Transcriptomic profiling of neural cultures from the KYOU iPSC line via alternative differentiation protocols

Frontiers in Molecular Neuroscience
The differentiation of pluripotent stem cells into neurons is an essential area of biomedical research, with significant implications for understanding neural development and treating neurological diseases.
Adelya Galiakberova, Sergey Ivanov, Sergey Ivanov, Arkadiy Golov, Alexander Artyuhov, Alexander Artyuhov, Alexey Zolkin, Alexey Zolkin, Nikolay Kondratyev, Alexey Lagunin, Alexey Lagunin, Vera Golimbet, Erdem Dashinimaev, Erdem Dashinimaev, Erdem Dashinimaev, Erdem Dashinimaev   +15 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Can a competitive neural network explain selective attention in insect target tracking neurons?

, 2013
Small target motion detecting (STMD) neurons in the dragonfly brain are neural correlates of a highly-specialized and ethologically-significant feature detection function, and the recent discovery of selective attention in STMDs has clear implications ...
Steven D. Wiederman, O'Carroll, D., Shoemaker, P., Patrick A. Shoemaker, Wiederman, S., David C. O'Carroll   +5 more
core   +1 more source

The role of inhibition in modeling decision making with spiking neural networks

Frontiers in Neuroinformatics
Decision making (DM) requires coordination of elementary information processes subserved by a distributed network of brain areas. Computational models help to understand these processes, but most of the existing models focus on simulating only one of the
Bartłomiej Król-Józaga, Peter Duggins, Anna Broniec-Wójcik, Szymon Wichary   +3 more
doaj   +1 more source

Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation

Scientific Reports, 2019
Inhibitory neural control of antagonist muscle is one of the fundamental neural mechanism of coordinated human limb movement. Previous studies have revealed that motor execution (ME) and motor imagery (MI) share many common neural substrates; however ...
Toshiyuki Aoyama, Fuminari Kaneko, Yukari Ohashi, Yutaka Kohno   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Posteriorizing factor Gbx2 is a direct target of Wnt signalling during neural crest induction [PDF]

, 2015
Wnt signalling is required for neural crest induction; however the direct targets of the Wnt pathway during neural crest induction remain unknown. I show here that the homeobox gene Gbx2 is essential in this process and is directly activated by Wnt/β ...
Li, B
core  

A push-pull CORF model of a simple cell with antiphase inhibition improves SNR and contour detection. [PDF]

, 2014
We propose a computational model of a simple cell with push-pull inhibition, a property that is observed in many real simple cells. It is based on an existing model called Combination of Receptive Fields or CORF for brevity. A CORF model uses as afferent
Rodriguez-Sanchez, Antonio, Petkov, Nicolai, George Azzopardi, Nicolai Petkov, Antonio Rodríguez-Sánchez, Azzopardi, George, Azzopardi, George; id_orcid, Justus Piater, Piater, Justus   +8 more
core   +3 more sources