Results 61 to 70 of about 322,061 (265)

Neural correlates of central inhibition during physical fatigue. [PDF]

PLoS ONE, 2013
Central inhibition plays a pivotal role in determining physical performance during physical fatigue. Classical conditioning of central inhibition is believed to be associated with the pathophysiology of chronic fatigue.
Masaaki Tanaka, Akira Ishii, Yasuyoshi Watanabe   +2 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Transcriptomic profiling of neural cultures from the KYOU iPSC line via alternative differentiation protocols

Frontiers in Molecular Neuroscience
The differentiation of pluripotent stem cells into neurons is an essential area of biomedical research, with significant implications for understanding neural development and treating neurological diseases.
Adelya Galiakberova, Sergey Ivanov, Sergey Ivanov, Arkadiy Golov, Alexander Artyuhov, Alexander Artyuhov, Alexey Zolkin, Alexey Zolkin, Nikolay Kondratyev, Alexey Lagunin, Alexey Lagunin, Vera Golimbet, Erdem Dashinimaev, Erdem Dashinimaev, Erdem Dashinimaev, Erdem Dashinimaev   +15 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Suppression and facilitation of human neural responses

eLife, 2018
Efficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining five different ...
Michael-Paul Schallmo, Alexander M Kale, Rachel Millin, Anastasia V Flevaris, Zoran Brkanac, Richard AE Edden, Raphael A Bernier, Scott O Murray   +7 more
doaj   +1 more source

Regulating synchronous oscillations of cerebellar granule cells by different types of inhibition.

PLoS Computational Biology, 2021
Synchronous oscillations in neural populations are considered being controlled by inhibitory neurons. In the granular layer of the cerebellum, two major types of cells are excitatory granular cells (GCs) and inhibitory Golgi cells (GoCs).
Yuanhong Tang, Lingling An, Quan Wang, Jian K Liu   +3 more
doaj   +1 more source

P3 as a neural index of response inhibition. [PDF]

, 2015
This study aimed to identify which ERP are specifically related to response inhibition. Electrophysiological activity was recorded from 30 subjects, and was submitted to a temporospatial principal component analysis to detect and quantify the main components associated with response inhibition.
Lopez-Martin, Sara, Albert, Jacobo, Hoyos, Sandra, Sanchez-Carmona, Alberto, Carretie, Luis   +4 more
openaire   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Distinct neural circuits support incentivized inhibition [PDF]

NeuroImage, 2018
The ability to inhibit responses under high stakes, or "incentivized inhibition," is critical for adaptive impulse control. While previous research indicates that right ventrolateral prefrontal cortical (VLPFC) activity plays a key role in response inhibition, less research has addressed how incentives might influence this circuit. By combining a novel
Josiah K. Leong, Kelly H. MacNiven, Gregory R. Samanez-Larkin, Brian Knutson   +3 more
openaire   +2 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source