Results 51 to 60 of about 322,061 (265)

Closing in on the constitution of consciousness

Frontiers in Psychology, 2014
The science of consciousness is a nascent and thriving field of research that is founded on identifying the minimally sufficient neural correlates of consciousness.
Steven M. Miller
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes

Advanced Science
Inhibition is an important concept in cognitive neuroscience. Direct inhibition, characterized by the active suppression of stimuli, and competition‐induced inhibition, which involves ignoring irrelevant stimuli by prioritizing relevant ones, have ...
Zhenhong He, Yifan Du, Ziqi Fu, Youcun Zheng, Nils Muhlert, Barbara Sahakian, Rebecca Elliott   +6 more
doaj   +1 more source

Research on Lateral Inhibition Network Based on Cell Membrane Electrical Model

Photonics
Lateral inhibition is a prevalent occurrence within the biological neural system, enhancing the human brain’s ability to perceive edge information within a given scene.
Dao-Han Qi, Ming-Jie Sun, Qing-Zhong Cai
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex.

PLoS Biology, 2022
Fibroblast growth factor (FGF) is a neural inducer in many vertebrate embryos, but how it regulates chromatin organization to coordinate the activation of neural genes is unclear.
Claudia I Semprich, Lindsay Davidson, Adriana Amorim Torres, Harshil Patel, James Briscoe, Vicki Metzis, Kate G Storey   +6 more
doaj   +1 more source

Overcoming Depression by Inhibition of Neural Burst Firing [PDF]

Neuron, 2018
The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.
Daesoo, Kim, Eunji, Cheong, Hee-Sup, Shin   +2 more
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation

Scientific Reports, 2019
Inhibitory neural control of antagonist muscle is one of the fundamental neural mechanism of coordinated human limb movement. Previous studies have revealed that motor execution (ME) and motor imagery (MI) share many common neural substrates; however ...
Toshiyuki Aoyama, Fuminari Kaneko, Yukari Ohashi, Yutaka Kohno   +3 more
doaj   +1 more source