Results 51 to 60 of about 1,160,496 (247)

Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation

npj Parkinson's Disease
Neuromodulation therapy comprises a range of non-destructive and adjustable methods for modulating neural activity using electrical stimulations, chemical agents, or mechanical interventions.
Atefeh Asadi, Alex I. Wiesman, Christoph Wiest, Sylvain Baillet, Huiling Tan, Muthuraman Muthuraman   +5 more
doaj   +1 more source

Towards Clinical Diagnosis: Automated Stroke Lesion Segmentation on Multi-Spectral MR Image Using Convolutional Neural Network

IEEE Access, 2018
The patient with ischemic stroke can benefit most from the earliest possible definitive diagnosis. While a quantitative evaluation of the stroke lesions on the magnetic resonance images (MRIs) is effective in clinical diagnosis, manually segmenting the ...
Zhiyang Liu, Chen Cao, Shuxue Ding, Zhiang Liu, Tong Han, Sheng Liu   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions

Molecular Brain, 2019
Postsynaptic density protein 95 (PSD-95) is a pivotal postsynaptic scaffolding protein in excitatory neurons. Although the transport and regulation of PSD-95 in synaptic regions is well understood, dendritic transport of PSD-95 before synaptic ...
Ki-Seo Yoo, Kina Lee, Jun-Young Oh, Hyoeun Lee, Hyungju Park, Young Seok Park, Hyong Kyu Kim   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Active noise control algorithm based on a neural network and nonlinear input-output system identification model

Archives of Acoustics, 2013
The development of digital signal processors and the increase in their computing capabilities bring opportunities to employ algorithms with multiple variable parameters in active noise control systems.
Tomasz KRUKOWICZ
doaj  

Enhanced Land Use and Land Cover Classification Through Human Group-based Particle Swarm Optimization-Ant Colony Optimization Integration with Convolutional Neural Network [PDF]

, 2023
Moresh Mukhedkar, Chamandeep Kaur, D. Srinivasa Rao, Shweta Bandhekar, Mohammed Saleh Al Ansari, Maganti Syamala, Yousef A. Baker El–Ebiary   +6 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Anterior cingulate cortex and its input to the basolateral amygdala control innate fear response

Nature Communications, 2018
Brain circuits that control innate fear response are essential for an animal’s survival. Here, the authors report how the anterior cingulate cortex and its projection to amygdala control the innate fear response in mice.
Jinho Jhang, Hyoeun Lee, Min Soo Kang, Han-Sol Lee, Hyungju Park, Jin-Hee Han   +5 more
doaj   +1 more source