Results 51 to 60 of about 2,503,125 (316)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

From vegetation to vulnerability: Integrating remote sensing and AI to combat cheatgrass-induced wildfire hazards in California

Environmental and Sustainability Indicators
Wildfire risk is on the rise around the world. In places like California, this risk is further instigated by the invasive species cheatgrass (Bromus tectorum).
Srikantnag A. Nagaraja, Istvan Kereszy, Chang Zhao, Imre Bartos   +3 more
doaj   +1 more source

Optimized multi layer perceptron artificial neural network based fault diagnosis of induction motor using vibration signals

Diagnostyka, 2021
Installations and the detection of their faults has become a major challenge. In order to develop a reliable approach for monitoring and diagnosis faults of these components, a test rig was mounted.
Khoualdia Tarek, lakehal Abdelaziz, Chelli Zoubir, Khoualdia Kais, Nessaib Karim   +4 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Abundant exact solutions of higher-order dispersion variable coefficient KdV equation

Open Physics, 2022
In this article, various exact solutions of the fifth-order variable coefficient KdV equation with higher-order dispersion term are studied. Because of the complexity of the exact solution of the variable coefficient t, it has a certain influence on the ...
Zhao Zhen, Pang Jing
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Significant subgraph mining for neural network inference with multiple comparisons correction

Network Neuroscience, 2023
We describe how the recently introduced method of significant subgraph mining can be employed as a useful tool in neural network comparison. It is applicable whenever the goal is to compare two sets of unweighted graphs and to determine differences in ...
Aaron J. Gutknecht, Michael Wibral
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source