Results 61 to 70 of about 1,761,761 (285)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Reluplex: An Efficient SMT Solver for Verifying Deep Neural Networks
, 2017 Deep neural networks have emerged as a widely used and effective means for tackling complex, real-world problems. However, a major obstacle in applying them to safety-critical systems is the great difficulty in providing formal guarantees about their ...
C Barrett +16 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Model-free decision-making underlies motor errors in rapid sequential movements under threat
Communications PsychologyOur movements, especially sequential ones, are usually goal-directed, i.e., coupled with task-level goals. Consequently, cognitive strategies for decision-making and motor performance are likely to influence each other. However, evidence linking decision-
Pranav Sankhe, Masahiko Haruno
doaj +1 more source
Revolution in flow cytometry: using artificial intelligence for data processing and interpretation [PDF]
European Journal of Translational and Clinical MedicineFlow cytometry (FC) represents a pivotal technique in the domain of biomedical research, facilitating the analysis of the physical and biochemical properties of cells. The advent of artificial intelligence (AI) algorithms has marked a significant turning
Szymon Bierzanowski +2 more
doaj +1 more source
Brain Sciences, 2022 Previous studies have revealed drastic changes in motor processing in individuals with congenital or acquired limb deficiencies and dysfunction. However, little is known about whether their brains also exhibit characteristic proprioceptive processing ...
Tomoyo Morita, Eiichi Naito
doaj +1 more source
Analysis of Neural Networks in Terms of Domain Functions [PDF]
, 2002 Despite their success-story, artificial neural networks have one major disadvantage compared to other techniques: the inability to explain comprehensively how a trained neural network reaches its output; neural networks are not only (incorrectly) seen as
Slump, Cees +2 more
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
NeuroImage, 2021 Olfaction could prove to be an early marker of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. To use olfaction for disease diagnosis, elucidating the standard olfactory functions in healthy humans is necessary.
Yuka Donoshita +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source