Results 81 to 90 of about 1,761,761 (285)

Cortical representational geometry of diverse tasks reveals subject-specific and subject-invariant cognitive structures

Communications Biology
The variability in brain function forms the basis for our uniqueness. Prior studies indicate smaller individual differences and larger inter-subject correlation (ISC) in sensorimotor areas than in the association cortex.
Tomoya Nakai, Rieko Kubo, Shinji Nishimoto   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Efficient musculoskeletal annotation using free-form deformation

Scientific Reports
Traditionally, constructing training datasets for automatic muscle segmentation from medical images involved skilled operators, leading to high labor costs and limited scalability.
Norio Fukuda, Shoji Konda, Jun Umehara, Masaya Hirashima   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Structural and functional features characterizing the brains of individuals with higher controllability of motor imagery

Scientific Reports
Motor imagery is a higher-order cognitive brain function that mentally simulates movements without performing the actual physical one. Although motor imagery has attracted the interest of many researchers, and mental practice utilizing motor imagery has ...
Tomoya Furuta, Tomoyo Morita, Gen Miura, Eiichi Naito   +3 more
doaj   +1 more source

Non-attracting Regions of Local Minima in Deep and Wide Neural Networks

, 2020
Understanding the loss surface of neural networks is essential for the design of models with predictable performance and their success in applications.
Petzka, Henning, Sminchisescu, Cristian
core  

Artificial neural networks [PDF]

, 2017
Nowadays we are living in the age of computers, and we are systematically making our way to creating artificial intelligence. In addition, one of possible directions to make AI come true is to find the way of generalizing ...
Korotenko, L.M., Nechai, N.M., Teslenko, Svyatoslav   +2 more
core  

Thermodynamic Neural Network

Entropy, 2020
A thermodynamically motivated neural network model is described that self-organizes to transport charge associated with internal and external potentials while in contact with a thermal reservoir. The model integrates techniques for rapid, large-scale, reversible, conservative equilibration of node states and slow, small-scale, irreversible, dissipative
openaire   +5 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source