Results 91 to 100 of about 1,681,568 (307)

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Evaluation and comparison of natural and synthetic retinoids on model of neural development [PDF]

, 2008
Vitamin A and its derivatives, collectively termed retinoids, are a group of natural and synthetic molecules that are structurally and/or functionally analogous.
Buyers Christie, Victoria
core  

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons. [PDF]

, 2014
Members of the transforming growth factor (TGF)-b family govern a wide range of mechanisms in brain development and in the adult, in particular neuronal/glial differentiation and survival, but also cell cycle regulation and neural stem cell maintenance ...
Strauss, O., Aigner, L., Lehner, B., Kraus, Sabrina, Strauss, Olaf, Reitsamer, Herbert A., Marschallinger, Julia, Lehner, Bernadette, Couillard-Despres, Sebastien, Bogdahn, Ulrich, Couillard‐Despres, Sebastien, Kandasamy, M., Kraus, S., Couillard-Despres, S., Sander, P.R., Trümbach, Dietrich, Aigner, Ludwig, Bogdahn, U., Trümbach, D., Sander, Paul Ramm, Ramm Sander, Paul, Rivera, Francisco J., Ueberham, Uwe, Marschallinger, J., Kandasamy, Mahesh, Reitsamer, H.A., Rivera, F.J., Ueberham, U.   +27 more
core   +1 more source

A Common Neural Progenitor for the CNS and PNS

Developmental Biology, 1998
Cultured spinal cord neuroepithelial (NEP) cells can differentiate into neurons, oligodendrocytes and astrocytes and are morphologically and antigenically distinct from neural crest stem cells (NCSCs) that generate the PNS. NEP cells, however, can generate p75/nestin-immunoreactive cells that are morphologically and antigenically similar to previously ...
Mujtaba, T., Mayer-Proschel, M., Rao, M.S.   +2 more
openaire   +2 more sources

Strain-Dependent Consequences of Zika Virus Infection and Differential Impact on Neural Development

Viruses, 2018
Maternal infection with Zika virus (ZIKV) during pregnancy can result in neonatal abnormalities, including neurological dysfunction and microcephaly. Experimental models of congenital Zika syndrome identified neural progenitor cells as a target of viral ...
Forrest T. Goodfellow, Katherine A. Willard, Xian Wu, Shelley Scoville, Steven L. Stice, Melinda A. Brindley   +5 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Enhancement of endogenous midbrain neurogenesis by microneurotrophin BNN-20 after neural progenitor grafting in a mouse model of nigral degeneration [PDF]

We have previously shown the neuroprotective and pro-neurogenic activity of microneurotrophin BNN-20 in the substantia nigra of the “weaver” mouse, a model of progressive nigrostriatal degeneration.
Nasia Antoniou, Efthymia Theodorou, Ilias Kazanis, Maria Anesti, Panagiota Nti Kostantzo, Theodora Mourtzi, Fevronia Angelatou, Christina Dimitriou, Georgia Athanasopoulou, Rebecca Matsas, Georgia Kouroupi, Olga Stathi, Panagiotis Gkaravelas   +12 more
core   +1 more source

Evaluation of the Expansion and Neuronal Differentiation Potency of Cultured Olfactory Epithelium Progenitor Cells from a Rat Model of Depression

Journal of Integrative Neuroscience
Background: Olfactory impairment has been reported in patients with depression and in rodent models of depression. Olfactory epithelium (OE) is the only peripheral neural tissue connected to the brain that has the potential for self-renewal.
Liang Chen, Yangzhi Xie, Jiacheng Chen, Yan Luo   +3 more
doaj   +1 more source