Results 121 to 130 of about 1,681,568 (307)

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

Cell Reports, 2019
Summary: The molecular basis of the earliest neuronal changes that lead to Alzheimer’s disease (AD) is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene-edited and control induced pluripotent stem cells (iPSCs). We observe
Katharina Meyer, Heather M. Feldman, Tao Lu, Derek Drake, Elaine T. Lim, King-Hwa Ling, Nicholas A. Bishop, Ying Pan, Jinsoo Seo, Yuan-Ta Lin, Susan C. Su, George M. Church, Li-Huei Tsai, Bruce A. Yankner   +13 more
doaj   +1 more source

Magnetoelectric BaTiO3/CoFe2O4 Thin‐Film Meshes for Neuronal Differentiation

Advanced Science, EarlyView.
We engineer an epitaxial BaTiO3/CoFe2O4 magnetoelectric mesh that overcomes boundary‐induced mechanical clamping. Progressively reducing the mechanical constraint, from substrate‐clamped to PDMS‐transferred and ultimately freestanding, enhances magnetic‐to‐electric transduction and strengthens magnetoelectric coupling.
Mathieu Mirjolet, Hao Ye, Abderrahim Lahlahi Attalhaoui, Donghoon Kim, Vitaly Pustovalov, Elric Zhang, Marc Tudela‐Pi, Bastian Gebauer, Juan Bautista Carda Castelló, Anton Guimerà‐Brunet, Josep Puigmartí‐Luis, Xiang‐Zhong Chen, Minsoo Kim, Salvador Pané   +13 more
wiley   +1 more source

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

Nature Communications, 2016
Glioma can originate from the transformation of neural progenitor cells into glioma initiating cells. Here, the authors demonstrate the use of induced pluripotent stem cells as a suitable model for generating neural progenitor cells, which can be ...
Ignacio Sancho-Martinez, Emmanuel Nivet, Yun Xia, Tomoaki Hishida, Aitor Aguirre, Alejandro Ocampo, Li Ma, Robert Morey, Marie N. Krause, Andreas Zembrzycki, Olaf Ansorge, Eric Vazquez-Ferrer, Ilir Dubova, Pradeep Reddy, David Lam, Yuriko Hishida, Min-Zu Wu, Concepcion Rodriguez Esteban, Dennis O’Leary, Geoffrey M. Wahl, Inder M. Verma, Louise C. Laurent, Juan Carlos Izpisua Belmonte   +22 more
doaj   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Caracterização e expansão in vitro de células tronco epidermais derivadas da crista neural [PDF]

, 2013
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.A implementação de tecnologias baseadas no uso de células tronco adultas requer a identificação de fontes prontamente disponíveis bem como o estabelecimento ...
Bressan, Raul Bardini
core  

Neurogenesis Mediated by γ-Aminobutyric Acid and Glutamate Signaling

Journal of Pharmacological Sciences, 2009
.: In this review, we will summarize our ongoing studies on the functionality of both γ-aminobutyric acid (GABA) and glutamate receptors expressed by undifferentiated neural progenitor cells isolated from embryonic rodent brains. Cells were cultured with
Noritaka Nakamichi, Takeshi Takarada, Yukio Yoneda   +2 more
doaj   +1 more source

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells [PDF]

, 2003
Background— Transplantation of ex vivo expanded circulating endothelial progenitor cells (EPCs) from peripheral blood mononuclear cells improves the neovascularization after critical ischemia. However, the origin of the endothelial progenitor lineage and
Dimmeler, S, Heeschen, C, Aicher, A, Urbich, C, Zeiher, AM, Dernbach, E   +5 more
core  

Shc signaling in differentiating neural progenitor cells

, 2001
Previously we found that the availability of ShcA adapter is maximal in neural stem cells but that it is absent in mature neurons. Here we report that ShcC, unlike ShcA, is not present in neural stem/progenitor cells, but is expressed after cessation of ...
L. Bonfanti, Luciano Conti, Luca Bonfanti, Marc Peschanski, M. Peschanski, Dorotea Rigamonti, Lorenzo Magrassi, Giuliana Pelicci, Bassam Haddad, G. Milanesi, S. Sipione, Elena Cattaneo, MAGRASSI, LORENZO, E. Cattaneo, P. Pelicci, G. Pelicci, D. Rigamonti, Simonetta Sipione, Gabriele Milanesi, L. Conti, Valentina Pettirossi, PierGiuseppe Pelicci, B. Haddad, V. Pettirossi, Sipione S, Peschanski M, Pelicci P, Bonfanti L, Cattaneo E., Bonfanti, Luca, Rigamonti D, Magrassi L, Conti L, PELICCI, Giuliana, Pettirossi V, Haddad B, Milanesi G   +36 more
core   +1 more source

: IQGAP1 regulates neural progenitor migration. [PDF]

, 2007
International audienceIn the germinative zone of the adult rodent brain, neural progenitors migrate into niches delimited by astrocyte processes and differentiate into neuronal precursors.
Grunwald, Didier, Deloulme, Jean-Christophe, Bouron, Alexandre, Bernards, André, Baudier, Jacques, Balenci, Laurent, Saoudi, Yasmina   +6 more
core   +1 more source