Results 191 to 200 of about 6,298,151 (304)

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cells. [PDF]

iScience
Balzano E, Twayana S, Kosiyatrakul ST, Logsdon GA, Thakur BL, Eichler EE, Bohl B, Koch P, Sidoli S, Kumari A, Munson KM, Hoekzema K, Aladjem MI, Schildkraut CL.   +13 more
europepmc   +1 more source

STRIDE: A Sequencing Depth Robust Metric for Sparse Chromosome Conformation Capture Data Comparison

Advanced Science, EarlyView.
A mean first passage time (MFPT)‐based representation transforms sparse Hi‐C contact maps into robust topological representations, preserving biologically meaningful chromatin features and facilitating robust analysis of TADs, chromatin loops, differential chromatin contacts, and sparse single‐cell Hi‐C data.
Bingxiang Xu, Xiaomeng Gao, Weichu Tao, Zhihua Zhang, Feifei Li   +4 more
wiley   +1 more source

Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids. [PDF]

Mol Psychiatry
Yentür Z, Branco L, Sarieva K, Andreeva D, Kagermeier T, Kulka C, Jarboui MA, Colombo F, Diaz F, Collignon P, Becker K, Selhuber-Unkel C, Mayer S.   +12 more
europepmc   +1 more source

RUNX1‐Mediated Hypoxic Signaling Impairs Myogenesis and Promotes Fibrosis in Myopathies

Advanced Science, EarlyView.
Myofiber overgrowth was associated with reduced blood flow and a potential hypoxic state in broiler breast muscle, accompanied by increased RUNX1 expression. Elevated RUNX1 impaired myogenic regeneration, promoted fibrosis, and disrupted the signaling niche required for efficient muscle repair, contributing to pathological degeneration in Wooden Breast
Liang Zhao, Taijiang Hou, Lin Zhang, Feng Gao, Tong Xing   +4 more
wiley   +1 more source

Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons. [PDF]

Nucleic Acids Res
Karlsson O, Pandiloski N, Horvath V, Adami A, Garza R, Johansson PA, Johansson JG, Douse CH, Jakobsson J.   +8 more
europepmc   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Dynamic transcriptomic remodeling in grafted human neural progenitor cells uncovers mechanisms for vision preservation in a rat model of retinitis pigmentosa. [PDF]

Nat Commun
Shahin S, Bell S, Lu B, Banerjee S, Swarup V, Xu H, Chetsawang J, Ramirez S, Alfaro JS, Laperle A, Svendsen S, Svendsen CN, Wang S.   +12 more
europepmc   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

The immunological profile of RC17 hESC-derived dopaminergic neural progenitor cells in vitro: Implications for the STEM-PD clinical trial. [PDF]

Stem Cell Reports
Curle AJ, Fazal SV, Qarin S, Howlett SK, He X, Stamper A, Pisupati V, Barker RA, Jones JL.   +8 more
europepmc   +1 more source