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Neural Progenitor Cells Regulate Microglia Functions and Activity [PDF]

Nature Neuroscience, 2012
We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis.
Tony Wyss-Coray, Raphael Guzman, Kira I Mosher   +2 more
exaly   +3 more sources

Proliferation Control in Neural Stem and Progenitor Cells [PDF]

Nature Reviews Neuroscience, 2015
Neural circuit function can be drastically affected by variations in the number of cells that are produced during development or by a reduction in adult cell number owing to disease. For this reason, unique cell cycle and cell growth control mechanisms operate in the developing and adult brain.
Jürgen Knoblich, Catarina Homem
exaly   +3 more sources

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Neural Stem Cells: Progenitors or Panacea?

Developmental Neuroscience, 2004
Are neural stem cells (NSCs) maintained as totipotent precursors by the specialized environment within the stem cell niche or are they simply progenitors, which, while retaining their ability to proliferate, are parcellated and restricted along with their postmitotic brethren?
Corinna, Klein, Gord, Fishell
openaire   +2 more sources

Neural Crest Stem and Progenitor Cells

Annual Review of Cell and Developmental Biology, 2006
Neural crest cells are a multipotent, migratory cell population that generates an astonishingly diverse array of cell types during vertebrate development. These include bones; tendons; neurons; glia; melanocytes; and connective, endocrine, and adipose tissue.
Jennifer F, Crane, Paul A, Trainor
openaire   +2 more sources

Glia as neural progenitor cells

Trends in Neurosciences, 2003
Recent studies have substantially expanded our conception of the roles for glia in function and maintenance of the adult nervous system. Of these reports, several have re-examined the lineage relationships among neural stem cells, their early radial glial derivatives and their mitotically competent neurogenic daughters.
openaire   +2 more sources

Monitoring Autophagy in Neural Stem and Progenitor Cells

2022
Autophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration.
Filippelli, Romina L., Kamyabiazar, Samaneh, Chang, Natasha C.   +2 more
openaire   +3 more sources

Neural progenitors and stem cells: mechanisms of progenitor heterogeneity

Current Opinion in Neurobiology, 1998
Heterogeneity among progenitor cells in the vertebrate nervous system has been documented with increasing frequency over the past few years. It has become clear that differences in progenitor cells help to determine when and how they respond to environmental signals.
openaire   +2 more sources

Shc signaling in differentiating neural progenitor cells

Nature Neuroscience, 2001
Previously we found that the availability of ShcA adapter is maximal in neural stem cells but that it is absent in mature neurons. Here we report that ShcC, unlike ShcA, is not present in neural stem/progenitor cells, but is expressed after cessation of their division and becomes selectively enriched in mature neurons.
L. Conti, S. Sipione, L. Magrassi, L. Bonfanti, D. Rigamonti, V. Pettirossi, M. Peschanski, B. Haddad, P. Pelicci, G. Milanesi, G. Pelicci, E. Cattaneo   +11 more
openaire   +5 more sources

Effects of GM-CSF on the neural progenitor cells

NeuroReport, 2004
Granulocyte macrophage colony stimulating factor (GM-CSF) is a potent hematopoietic cytokine, which stimulates stem cell proliferation in the bone marrow. We now report that GM-CSF receptors expressed on neural progenitor cells and can mediate a biological response in cells to treat with GM-CSF treated neural progenitor cells exhibited a proliferative ...
Jin Kyun, Kim, Byung Hyun, Choi, Hyung Chun, Park, So Ra, Park, Young Soo, Kim, Seung Hwan, Yoon, Hyun Seon, Park, Eun Young, Kim, Yoon, Ha   +8 more
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Neural Differentiation of Rodent Neural Progenitor Cells and Isolation and Enrichment of Human Neural Progenitor/Stem Cells

2016
Neural progenitor cells (NPC) are multipotent and give rise to neurons, astrocytes and oligodendrocytes. NPC possess the ability of in vivo and in vitro proliferation and can therefore be expanded for research proposes. Cell proliferation generates a three dimensional aggregate called neurospheres; posteriorly, these neurospheres can be differentiated ...
Antonio H. Martins, Jose L. Roig-Lopez, Maxine Nicole Gonzalez   +2 more
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