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Osteopontin increases the proliferation of neural progenitor cells
International Journal of Developmental Neuroscience, 2012AbstractWe examined the role of osteopontin in the proliferation of neural progenitor cellsin vitro. Osteopontin increased the proliferation of neural progenitor cells in the presence of FGF2 as measured by cell proliferation assay and bromodeoxy uridine incorporation studies.
Haviryaji S G, Kalluri +1 more
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Effect of oxidative preconditioning on neural progenitor cells
Brain Research, 2008Neural progenitor cells (NPCs) have drawn attention because they offer possible treatment for neurodegenerative disorders in the form of regenerative therapy or transplantation. NPCs adapt and change in response to the cues in the pathological environment.
Rajesh K, Sharma +2 more
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PACAP and Neural Progenitor Cells
2016PACAP is a neuropeptide with a multitude of functions on different cell types and organs including brain tissue. PACAP is relatively highly expressed in embryonic brain indicating a role in neuronal development. Particularly PACAP is expressed in the subventricular zone of lateral ventricles and in the dentate gyrus of hippocampus harboring the neural ...
Dan Lindholm +2 more
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Neurotrophin channeling of neural progenitor cell differentiation
Journal of Neurobiology, 2001The act of defining neuropoietic progenitor/stem cells is still in its early phases. Epidermal growth factor (EGF) stimulates extended proliferation of aggregates of subventricular striatal cells, taken from E15 mouse striatum, termed neurospheres in liquid culture.
B O, Benoit +8 more
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Transplantation of neural progenitor cells into the human CNS
Trends in Molecular Medicine, 2022The development of regenerative medicine for spinal cord injury (SCI) and intractable diseases of the nervous system using neural progenitor cells (NPCs) has shown great promise, and several clinical trials have begun. In addition, ex vivo gene therapy using genetically engineered NPCs was recently initiated in the clinical setting by Baloh et al ...
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Vertebrate neural progenitor cells: subtypes and regulation
Current Opinion in Neurobiology, 1996Several advances have been made recently in characterizing neural progenitor cells. In vertebrates, multipotential stem cells have been demonstrated in the developing forebrain both in vitro and in vivo, and a class of stem cells has been identified in the adult CNS.
S, Temple, X, Qian
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L1 Retrotransposition in Neural Progenitor Cells
2016Long interspersed nucleotide element 1 (LINE-1 or L1) is a family of non-LTR retrotransposons that can replicate and reintegrate into the host genome. L1s have considerably influenced mammalian genome evolution by retrotransposing during germ cell development or early embryogenesis, leading to massive genome expansion.
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Expression of cytokines by multipotent neural progenitor cells
Cytokine, 2003Recent work with mammalian neural stem cells has highlighted the role of cytokine signaling in the proliferation and differentiation of these multipotent cells. While the responsiveness of neural progenitors to exogenously applied growth factors has been demonstrated in vivo as well as in vitro, little attention has been given to the production of ...
Henry J, Klassen +6 more
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Regulation of neural progenitor cell fate by anandamide
Biochemical and Biophysical Research Communications, 2010Exogenous application of neural progenitor cells (NPCs) has successful implications in treating brain disorders, and research is beginning to identify ways to mimic this exogenous application by activating endogenous stem cell compartments. The recent discovery of a functional endocannabinoid system in murine NPCs (mNPCs) represents one potential ...
John, Soltys +2 more
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Telomerase immortalization of human neural progenitor cells
NeuroReport, 2004It is necessary to expand human neural progenitor cells in vitro to obtain large numbers for research purposes and cell transplantation. A potential obstacle to in vitro expansion, however, is that neural progenitor cells have a limited replication life-span and gradually lose their differentiation potential.
Yun, Bai +6 more
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