Results 51 to 60 of about 2,880,253 (278)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
MicromachinesThis study proposes a rigid-flexible neural optrode integrated with anti-bending SU-8 optical waveguides and locally soft peptide-functionalized microelectrodes to address the challenges of precise implantation and long-term biocompatibility in ...
Minghao Wang +11 more
doaj +1 more source
Minimally-Invasive Neural Interface for Distributed Wireless Electrocorticogram Recording Systems
Sensors, 2018 This paper presents a minimally-invasive neural interface for distributed wireless electrocorticogram (ECoG) recording systems. The proposed interface equips all necessary components for ECoG recording, such as the high performance front-end integrated ...
Sun-Il Chang, Sung-Yun Park, Euisik Yoon
doaj +1 more source
Nature CommunicationsBioresorbable neural implants based on emerging classes of biodegradable materials offer a promising solution to the challenges of secondary surgeries for removal of implanted devices required for existing neural implants.
M. Cho +19 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
An Inductively-Powered Wireless Neural Recording and Stimulation System for Freely-Behaving Animals
IEEE Transactions on Biomedical Circuits and Systems, 2019 An inductively-powered wireless integrated neural recording and stimulation (WINeRS-8) system-on-a-chip (SoC) that is compatible with the EnerCage-HC2 for wireless/battery-less operation has been presented for neuroscience experiments on freely behaving ...
Byunghun Lee +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Hemispherical Microelectrode Array for Ex Vivo Retinal Neural Recording
Micromachines, 2020 To investigate the neuronal visual encoding process in the retina, researchers have performed in vitro and ex vivo electrophysiological experiments using animal retinal tissues.
Yoonhee Ha +3 more
doaj +1 more source
Dimensionality reduction for large-scale neural recordings [PDF]
Nature Neuroscience, 2014 Most sensory, cognitive and motor functions depend on the interactions of many neurons. In recent years, there has been rapid development and increasing use of technologies for recording from large numbers of neurons, either sequentially or simultaneously.
John P, Cunningham, Byron M, Yu
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source