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Cytokines in neural regeneration
Current Opinion in Neurobiology, 1992Growth factors with already established multiple effects on non-neural cells continue to be of considerable interest to researchers with regard to the nervous system, where regulation of cell maintenance and plasticity in relation to lesion and regeneration is part of their functional repertoire.
Claudia Grothe +3 more
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Approaches for Neural Tissue Regeneration
Stem Cell Reviews and Reports, 2013There is currently no treatment for neurodegenerative diseases such as Parkinson's or Alzheimer's diseases. While spinal cord injury has no treatment either, nerve injuries are being treated with autologous grafts, a procedure that in turn translates into a loss of function in the donor area.
Abdellah Ajji +3 more
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2012
Regeneration of the nervous system requires either the repair or replacement of nerve cells that have been damaged by injury or disease. While lower organisms possess extensive capacity for neural regeneration, evolutionarily higher organisms including humans are limited in their ability to regenerate nerve cells, posing significant issues for the ...
Melissa M, Steward +2 more
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Regeneration of the nervous system requires either the repair or replacement of nerve cells that have been damaged by injury or disease. While lower organisms possess extensive capacity for neural regeneration, evolutionarily higher organisms including humans are limited in their ability to regenerate nerve cells, posing significant issues for the ...
Melissa M, Steward +2 more
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The Molecular Basis of Neural Regeneration
Neurosurgery, 2003THE CENTRAL NERVOUS SYSTEM (CNS) is incapable of meaningful regeneration of lost neurons or axonal and dendritic connections after injury. This often results in permanent and severe loss of neurological function. The CNS regenerative process is unsuccessful for at least three reasons: neurons are highly susceptible to death after CNS injury; the CNS ...
Michael G. Fehlings, W. Bradley Jacobs
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Neural ECM in regeneration and rehabilitation
2014Neural extracellular matrix (ECM) is different from the normal ECM in other organs in that it has low fibrous protein content and high carbohydrate content. One of the key carbohydrate components in the brain ECM is chondroitin sulfate proteoglycans (CSPGs).
Sujeong Yang +2 more
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Neural Regeneration: Lessons from Regenerating and Non-regenerating Systems
Molecular Neurobiology, 2012One only needs to see a salamander regrowing a lost limb to become fascinated by regeneration. However, the lack of robust axonal regeneration models for which good cellular and molecular tools exist has hampered progress in the field. Nevertheless, the nervous system has been revealed to be an excellent model to investigate regeneration.
Giorgia Quadrato +3 more
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Emerging roles for semaphorins in neural regeneration
Brain Research Reviews, 2001Progressive axon outgrowth during neural development contrasts with the failure of regenerative neurite growth in the mature mammalian central nervous system (CNS). During neuroembryogenesis, spatiotemporal patterns of repellent and attractant activities in the vicinity of the growth cone favor neurite outgrowth.
R. Jeroen Pasterkamp, Joost Verhaagen
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Neural regeneration in gastropod molluscs
Progress in Neurobiology, 1995Snails recover function following a variety of neural injuries. They grow new tentacles with associated tentacle ganglia, selectively reinnervate peripheral targets, repair central connections and may even replace lost neurons and ganglia. The plasticity revealed in their responses to neural injury is an extreme expression of the adaptability observed ...
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How the Neural Retina Regenerates
2000The rules that govern cellular behavior during development and regeneration of tissues are complex and enigmatic, but substantial progress is being made toward understanding the molecular basis of proliferation and differentiation. Although most of the recent mechanistic insights have been gained from studies of embryonic development, the capacity of ...
Pamela A. Raymond, Peter F. Hitchcock
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