Results 91 to 100 of about 448,417 (306)

Protocol for differentiating human pluripotent stem cells into midbrain organoids for targeted microinjection of viruses

STAR Protocols
Summary: Midbrain organoids serve as a valuable model for studying brain development and disease. Here, we present a viral infection protocol for midbrain organoid models.
Mengdan Tao, Qi Chen, WeiWei Gao, Shanshan Wu, Yan Liu   +4 more
doaj   +1 more source

MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex

eLife, 2016
During the development, tight regulation of the expansion of neural progenitor cells (NPCs) and their differentiation into neurons is crucial for normal cortical formation and function.
Wei Zhang, Paul Jong Kim, Zhongcan Chen, Hidayat Lokman, Lifeng Qiu, Ke Zhang, Steven George Rozen, Eng King Tan, Hyunsoo Shawn Je, Li Zeng   +9 more
doaj   +1 more source

Molecular Crosstalk Between Circadian Rhythmicity and the Development of Neurodegenerative Disorders

Frontiers in Neuroscience, 2020
Neurodegenerative disorders have been shown to exhibit substantial interconnectedness with circadian rhythmicity. Alzheimer’s patients exhibit high degradation of the suprachiasmatic nucleus (SCN), the central endogenous circadian timekeeper, and ...
Arastu Sharma, Sehyun Lee, Hoonseo Kim, Hargsoon Yoon, Shinwon Ha, Sung Ung Kang   +5 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Retinoid Machinery in Distinct Neural Stem Cell Populations with Different Retinoid Responsiveness [PDF]

, 2013
Retinoic acid (RA) is present at sites of neurogenesis in both the embryonic and adult brain. While it is widely accepted that RA signaling is involved in the regulation of neural stem cell differentiation, little is known about vitamin A utilization ...
Adrienn Borsy, Barbara Orsolits, de The H, Emília Madarász, Ervin Welker, Károly Markó, Márta Jelitai, Toresson H, Tímea Kőhidi, Zsuzsanna Környei, Zsófia Mészáros   +10 more
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons

Stem Cell Reports, 2018
Summary: The brain of Down syndrome (DS) patients exhibits fewer interneurons in the cerebral cortex, but its underlying mechanism remains unknown. By morphometric analysis of cortical interneurons generated from DS and euploid induced pluripotent stem ...
Hai-Qin Huo, Zhuang-Yin Qu, Fang Yuan, Lixiang Ma, Lin Yao, Min Xu, Yao Hu, Jing Ji, Anita Bhattacharyya, Su-Chun Zhang, Yan Liu   +10 more
doaj   +1 more source

Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation. [PDF]

, 2017
Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), represent potentially unlimited cell sources for clinical applications. Previous studies have suggested that hPSCs may benefit from immune privilege and
Allard, Patrick, Chang, Kai-Wei, Chen, Hsin-Fu, Chou, Wen-Hsi, Ghelfi, Elisa, Ho, Hong-Nerng, Huang, Mei-Chi, Jan, Pey-Shynan, Lin, Shau-Ping, Lu, Chen-Yu, Wu, Chia-Eng, Wu, Fang-Chun, Yu, Chen-Wei   +12 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Current Status of Stem Cell-Derived Therapies for Parkinson’s Disease: From Cell Assessment and Imaging Modalities to Clinical Trials

Frontiers in Neuroscience, 2020
Curative therapies or treatments reversing the progression of Parkinson’s disease (PD) have attracted considerable interest in the last few decades. PD is characterized by the gradual loss of dopaminergic (DA) neurons and decreased striatal dopamine ...
Se Eun Jang, Lifeng Qiu, Ling Ling Chan, Ling Ling Chan, Eng-King Tan, Eng-King Tan, Li Zeng, Li Zeng, Li Zeng   +8 more
doaj   +1 more source