Results 1 to 10 of about 554,381 (309)

Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children

open access: yesFrontiers in Oncology, 2022
Acute lymphoblastic leukemia (ALL) is the most common malignancy among Mexican and Hispanic children and the first cause of death by disease in Mexico. We propose a “triple-hit” explanation for the survival gap affecting this population.
Roberto Rivera-Luna   +8 more
doaj   +1 more source

Characterization of The Retinal Progenitor Cells Generated Using Co-Culture Systems [PDF]

open access: yesCell Journal, 2022
Objective: Degeneration of the photoreceptors due to retinal disorders can affect vision, and even lead to blindness. Recently therapeutic progress in retinal degeneration, using human embryonic stem cells (hESCs), has been facing technical challenges,
Sara Momenzadeh   +3 more
doaj   +1 more source

HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity

open access: yeseLife, 2021
High-throughput single-cell methods have uncovered substantial heterogeneity in the pool of hematopoietic stem and progenitor cells (HSPCs), but how much instruction is inherited by offspring from their heterogeneous ancestors remains unanswered. Using a
Tamar Tak   +8 more
doaj   +1 more source

Endothelial Progenitor Cells [PDF]

open access: yesAnnual Review of Medicine, 2005
Endothelial progenitor cells are a circulating, bone marrow–derived cell population that appears to participate in both vasculogenesis and vascular homeostasis. Questions persist regarding their functional characteristics, as well as the precise panel of cell surface markers that uniquely define this newly described progenitor cell population.
Aarif Y, Khakoo, Toren, Finkel
openaire   +4 more sources

Bronchiolar Progenitor Cells [PDF]

open access: yesProceedings of the American Thoracic Society, 2009
A comprehensive appreciation of mechanisms regulating epithelial maintenance and repair in pulmonary airways is fundamental to our understanding of tissue remodeling and dysfunction in chronic lung disease. This review provides an update on current concepts that have emerged from recent work in the field of airway epithelial repair and progenitor cell ...
Huaiyong, Chen   +2 more
openaire   +2 more sources

Categorisation of patients based on immune profiles: a new approach to identifying candidates for response to checkpoint inhibitors

open access: yesClinical & Translational Immunology, 2021
Objectives Inhibitors to the checkpoint proteins cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) and programmed cell death protein 1 (PD‐1) are becoming widely used in cancer treatment.
Svetlana Bornschlegl   +11 more
doaj   +1 more source

Beneficial effects of reconstituted high-density lipoprotein (rHDL) on circulating CD34+ cells in patients after an acute coronary syndrome [PDF]

open access: yes, 2017
Background: High-density lipoproteins (HDL) favorably affect endothelial progenitor cells (EPC). Circulating progenitor cell level and function are impaired in patients with acute coronary syndrome (ACS).
Alam, Mohammad Afaque   +15 more
core   +11 more sources

Brain isoform glycogen phosphorylase as a novel hepatic progenitor cell marker. [PDF]

open access: yesPLoS ONE, 2015
An appropriate liver-specific progenitor cell marker is a stepping stone in liver regenerative medicine. Here, we report brain isoform glycogen phosphorylase (GPBB) as a novel liver progenitor cell marker.
Yu-Wen Huang   +6 more
doaj   +1 more source

Cell Therapy for Anal Sphincter Incontinence: Where Do We Stand?

open access: yesCells, 2021
Anal sphincter incontinence is a chronic disease, which dramatically impairs quality of life and induces high costs for the society. Surgery, considered as the best curative option, shows a disappointing success rate.
Alexandre Balaphas   +9 more
doaj   +1 more source

Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN

open access: yesFrontiers in Cell and Developmental Biology, 2022
Glycogen synthase kinase-3β (GSK-3β) is a downstream target of oncogenic KRas and can accumulate in the nucleus in pancreatic ductal adenocarcinoma (PDA).
Li Ding   +13 more
doaj   +1 more source

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