Results 11 to 20 of about 554,381 (309)

Single-nuclei analysis reveals depot-specific transcriptional heterogeneity and depot-specific cell types in adipose tissue of dairy cows

Frontiers in Cell and Developmental Biology, 2022
Adipose tissue (AT) is an endocrine organ with a central role on whole-body energy metabolism and development of metabolic diseases. Single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, respectively) analyses in mice and human AT have ...
Tainara C. Michelotti, Brent R. Kisby, Lauryn S. Flores, Alexandra P. Tegeler, Mohamed Fokar, Chiquito Crasto, Chiquito Crasto, Chiquito Crasto, Bruno C. Menarim, Shavahn C. Loux, Clarissa Strieder-Barboza, Clarissa Strieder-Barboza   +11 more
doaj   +1 more source

Hindlimb Immobilization Increases IL-1β and Cdkn2a Expression in Skeletal Muscle Fibro-Adipogenic Progenitor Cells: A Link Between Senescence and Muscle Disuse Atrophy

Frontiers in Cell and Developmental Biology, 2022
Loss of muscle mass and strength contributes to decreased independence and an increased risk for morbidity and mortality. A better understanding of the cellular and molecular mechanisms underlying muscle atrophy therefore has significant clinical and ...
Emily Parker, Andrew Khayrullin, Andrew Kent, Bharati Mendhe, Khairat Bahgat Youssef El Baradie, Khairat Bahgat Youssef El Baradie, Kanglun Yu, Jeanene Pihkala, Yutao Liu, Meghan McGee-Lawrence, Maribeth Johnson, Jie Chen, Mark Hamrick   +12 more
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Therapeutic Strategies for Dystrophin Replacement in Duchenne Muscular Dystrophy

Frontiers in Medicine, 2022
Duchenne muscular dystrophy (DMD) is an X-linked hereditary disease characterized by progressive muscle wasting due to modifications in the DMD gene (exon deletions, nonsense mutations, intra-exonic insertions or deletions, exon duplications, splice site
Cedric Happi Mbakam, Cedric Happi Mbakam, Gabriel Lamothe, Gabriel Lamothe, Jacques P. Tremblay, Jacques P. Tremblay   +5 more
doaj   +1 more source

Formaldehyde Fixation of Extracellular Matrix Protein Layers for Enhanced Primary Cell Growth

Bio-Protocol, 2017
Coating tissue culture vessels with the components of the extracellular matrix such as fibronectin and collagens provides a more natural environment for primary cells in vitro and stimulates their proliferation.
Natalia Andreeva, Alexander Belyavsky
doaj   +1 more source

Isolation and Expansion of Mesenchymal Stem Cells from Murine Adipose Tissue

Bio-Protocol, 2017
Mesenchymal stem cells (MSCs) are currently intensively studied due to significant promise which they represent for successful implementations of future cell therapy clinical protocols. This in turn emphasizes importance of careful preclinical studies of
Natalia Andreeva, Alexandra Dalina, Alexander Belyavsky   +2 more
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Hematopoiesis Remains Permissive to Bone Marrow Transplantation After Expansion of Progenitors and Resumption of Blood Cell Production

Frontiers in Cell and Developmental Biology, 2021
The immense regenerative power of hematopoietic tissue stems from the activation of the immature stem cells and the progenitor cells. After partial damage, hematopoiesis is reconstituted through a period of intense regeneration when blood cell production
Martin Báječný, Martin Báječný, Chia-Ling Chen, Kateřina Faltusová, Tomáš Heizer, Tomáš Heizer, Katarína Szikszai, Petr Páral, Petr Páral, Luděk Šefc, Emanuel Nečas   +10 more
doaj   +1 more source

Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate. [PDF]

, 2017
Adult stem cells commonly give rise to transit-amplifying progenitors, whose progeny differentiate into distinct cell types. It is unclear if stem cell niche signals coordinate fate decisions within the progenitor pool.
Burrous, Haley, Dai, Wei, Kenney, Thomas, Montell, Denise J, Peterson, Amy   +4 more
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Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes [PDF]

, 2003
Background - Further to promoting angiogenesis, cell therapy may be an approach for cardiac regeneration. Recent studies suggest that progenitor cells can transdifferentiate into other lineages. However, the transdifferentiation potential of endothelial
Aicher, A, Badorff, C, Brandes, RP, Busse, R, Dimmeler, S, Fleming, I, Popp, R, Rupp, S, Urbich, C, Zeiher, AM   +9 more
core   +1 more source

Hepatic progenitor cells from adult human livers for cell transplantation. [PDF]

, 2008
Objective: Liver regeneration is mainly based on cellular self-renewal including progenitor cells. Efforts have been made to harness this potential for cell transplantation, but shortage of hepatocytes and premature differentiated progenitor cells ...
Aurich, H., Brockhoff, G., Christ, B., Jauch, Karl-Walter, Kirchner, S., Kunz-Schughart, L.A., Lichtenauer, M., Schlitt, H.-J., Stock, P., Thasler, Wolfgang E., Weiss, T.S.   +10 more
core   +1 more source

Stable human cartilage progenitor cell line stimulates healing of meniscal tears and attenuates post-traumatic osteoarthritis

Frontiers in Bioengineering and Biotechnology, 2022
Meniscal tearing in the knee increases the risk of post-traumatic osteoarthritis (OA) in patients. The therapeutic application of tissue-specific mesenchymal progenitor cells is currently being investigated as an emerging biologic strategy to help ...
Salomi Desai, Mark Dooner, Jake Newberry, John Twomey-Kozak, Janine Molino, Jay Trivedi, Jay M. Patel, Brett D. Owens, Chathuraka T. Jayasuriya   +8 more
doaj   +1 more source