Results 111 to 120 of about 1,438,323 (398)
Effect of Dedifferentiation on Time to Mutation Acquisition in Stem Cell-Driven Cancers [PDF]
, 2013 Accumulating evidence suggests that many tumors have a hierarchical organization, with the bulk of the tumor composed of relatively differentiated short-lived progenitor cells that are maintained by a small population of undifferentiated long-lived cancer stem cells.
arxiv +1 more source
The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes [PDF]
, 2005 The boundary cap (BC) is a transient neural crest-derived group of cells located at the dorsal root entry zone (DREZ) that have been shown to differentiate into sensory neurons and glia in vivo.
Cederberg, A +6 more
core +1 more source
FEBS Open Bio, EarlyView.We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei +6 more
wiley +1 more source
Nature Communications, 2015 Decoding heterogeneity of pluripotent stem cell (PSC)-derived neural progeny is fundamental for revealing the origin of diverse progenitors, for defining their lineages, and for identifying fate determinants driving transition through distinct potencies.
Reuven Edri +12 more
semanticscholar +1 more source
Machine Learning and Medical Data: Predicting ICU Mortality and Re-admission Risks
Journal of Advanced Research in Natural and Applied SciencesIntensive care units (ICUs) are divisions where critically ill patients are treated by medical experts. The unmet and vital need for automated clinical decision-making mechanisms is critical to maneuvering the large influx of patients.
Runia Roy, Ulya Bayram
doaj +1 more source
Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus. [PDF]
, 2017 The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV).
Lane, Thomas E +4 more
core +1 more source
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
Molecular Crosstalk Between Circadian Rhythmicity and the Development of Neurodegenerative Disorders
Frontiers in Neuroscience, 2020 Neurodegenerative disorders have been shown to exhibit substantial interconnectedness with circadian rhythmicity. Alzheimer’s patients exhibit high degradation of the suprachiasmatic nucleus (SCN), the central endogenous circadian timekeeper, and ...
Arastu Sharma +5 more
doaj +1 more source
Theory of Robustness of Irreversible Differentiation in a Stem Cell System: Chaos hypothesis [PDF]
arXiv, 2000 Based on extensive study of a dynamical systems model of the development of a cell society, a novel theory for stem cell differentiation and its regulation is proposed as the ``chaos hypothesis''. Two fundamental features of stem cell systems - stochastic differentiation of stem cells and the robustness of a system due to regulation of this ...
arxiv
Identification of a neural crest stem cell niche by Spatial Genomic Analysis [PDF]
, 2017 The neural crest is an embryonic population of multipotent stem cells that form numerous defining features of vertebrates. Due to lack of reliable techniques to perform transcriptional profiling in intact tissues, it remains controversial whether the ...
Bronner, Marianne E. +4 more
core +4 more sources