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2008
Neural stem cells (NSCs) have been identified in the mature central nervous system (CNS), and they reside in specific areas. Cultures of NSCs can be successfully established in vitro by exploiting the NeuroSphere assay. This methodology relies on the continuous exposure of neural cells to mitogens such as epidermal growth factor and fibroblast growth ...
Galli, R +2 more
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Neural stem cells (NSCs) have been identified in the mature central nervous system (CNS), and they reside in specific areas. Cultures of NSCs can be successfully established in vitro by exploiting the NeuroSphere assay. This methodology relies on the continuous exposure of neural cells to mitogens such as epidermal growth factor and fibroblast growth ...
Galli, R +2 more
openaire +2 more sources
Glycobiology of Neural Stem Cells
CNS & Neurological Disorders - Drug Targets, 2006The mammalian central nervous system is organized by a variety of cells, such as neurons and glial cells, that are generated from a common progenitor, the neural stem cell (NSC). NSCs are defined as undifferentiated neural cells that are characterized by their high proliferative potential while retaining the capacity for self-renewal and multipotency ...
Robert K, Yu, Makoto, Yanagisawa
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2008
Neural stem cells (NSCs) are the self-renewing, multipotent cells that generate neurons, astrocytes, and oligodendrocytes in the nervous system. In the fetus, NSCs participate to the development of the nervous system. Stem cells are present in many tissues of adult mammals where they contribute to cellular homeostasis and regeneration after injury. The
Yang D. Teng +6 more
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Neural stem cells (NSCs) are the self-renewing, multipotent cells that generate neurons, astrocytes, and oligodendrocytes in the nervous system. In the fetus, NSCs participate to the development of the nervous system. Stem cells are present in many tissues of adult mammals where they contribute to cellular homeostasis and regeneration after injury. The
Yang D. Teng +6 more
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Proteomics of neural stem cells
Expert Review of Proteomics, 2008The isolation of neural stem cells from fetal and adult mammalian CNS and the demonstration of functional neurogenesis in adult CNS have offered perspectives for treatment of many devastating hereditary and acquired neurological diseases. Due to this enormous potential, neural stem cells are a subject of extensive molecular profiling studies with a ...
Helena, Skalnikova +3 more
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Neural stem cell heterogeneity
Progress in Neurobiology, 2018The ‘identity’ of the neural stem cell (NSC) in the adult mammalian brain has captivated the interest and imagination of scientists since the seminal findings in the 1990s revealing the existence of a unique subset of glial-like cells that fulfill the stem cell criteria of self-renewal and multipotentality.
Jean-Stéphane, Joly, Vincent, Tropepe
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Neural stem cells and cell death
Toxicology Letters, 2004Neural stem cells (NSC) undergo apoptotic cell death as an essential component of neural development. Here, we present the results of our studies on the mechanisms by which NSC undergo cell death in response to neurotoxic insults. As experimental models we used primary culture of adult NSC from the subventricular zone of the rat brain, and the neural ...
S, Ceccatelli +3 more
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Neural Stem Cells and Their Manipulation
2006Extracellular signals dictate the biological processes of neural stem cells (NSCs) both in vivo and in vitro. The intracellular response elicited by these signals is dependent on the context in which the signal is received, which in turn is decided by previous and concurrent signals impinging on the cell.
Prithi, Rajan, Evan, Snyder
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The development of neural stem cells
Nature, 2001The discovery of stem cells that can generate neural tissue has raised new possibilities for repairing the nervous system. A rush of papers proclaiming adult stem cell plasticity has fostered the notion that there is essentially one stem cell type that, with the right impetus, can create whatever progeny our heart, liver or other vital organ desires ...
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The culture of neural stem cells
Journal of Cellular Biochemistry, 2008AbstractA stem cell has three important features. Firstly, the ability of self‐renewal: making identical copies of itself. Secondly, multipotency, generating all the major cell lineages of the host tissue (in the case of embryonic stem cells—pluripotency). Thirdly, the ability to generate/regenerate tissues.
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Neural Induction and Neural Stem Cell Development
Regenerative Medicine, 2006Embryonic stem (ES) cells are a pluripotent and renewable cellular resource with tremendous potential for broad applications in regenerative medicine. Arguably the most important consideration for stem cell-based therapies is the ability to precisely direct the differentiation of stem cells along a preferred cellular lineage.
Lan, Dang, Vincent, Tropepe
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