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2008
Neural stem cells (NSCs) have been identified in the mature central nervous system (CNS), and they reside in specific areas. Cultures of NSCs can be successfully established in vitro by exploiting the NeuroSphere assay. This methodology relies on the continuous exposure of neural cells to mitogens such as epidermal growth factor and fibroblast growth ...
Galli, R +2 more
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Neural stem cells (NSCs) have been identified in the mature central nervous system (CNS), and they reside in specific areas. Cultures of NSCs can be successfully established in vitro by exploiting the NeuroSphere assay. This methodology relies on the continuous exposure of neural cells to mitogens such as epidermal growth factor and fibroblast growth ...
Galli, R +2 more
openaire +3 more sources
2010
Neural stem cells are the source of all neurons, astrocytes and oligodendrocytes of the central nervous system. While the vast majority of neural stem cells are consumed during embryonic development, a subpopulation persists in specialized regions of the adult mammalian brain where addition of cells, notably neurons, continues throughout life.
Yoko Arai +2 more
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Neural stem cells are the source of all neurons, astrocytes and oligodendrocytes of the central nervous system. While the vast majority of neural stem cells are consumed during embryonic development, a subpopulation persists in specialized regions of the adult mammalian brain where addition of cells, notably neurons, continues throughout life.
Yoko Arai +2 more
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Cell and Tissue Research, 2007
The neural stem cell niche defines a zone in which stem cells are retained after embryonic development for the production of new cells of the nervous system. This continual supply of new neurons and glia then provides the postnatal and adult brain with an added capacity for cellular plasticity, albeit one that is restricted to a few specific zones ...
Joanne C. Conover, Ryan Q. Notti
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The neural stem cell niche defines a zone in which stem cells are retained after embryonic development for the production of new cells of the nervous system. This continual supply of new neurons and glia then provides the postnatal and adult brain with an added capacity for cellular plasticity, albeit one that is restricted to a few specific zones ...
Joanne C. Conover, Ryan Q. Notti
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Glycobiology of Neural Stem Cells
CNS & Neurological Disorders - Drug Targets, 2006The mammalian central nervous system is organized by a variety of cells, such as neurons and glial cells, that are generated from a common progenitor, the neural stem cell (NSC). NSCs are defined as undifferentiated neural cells that are characterized by their high proliferative potential while retaining the capacity for self-renewal and multipotency ...
Makoto Yanagisawa, Robert K. Yu
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Embryonic stem cell lines derived from human blastocysts.
Science, 1998Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early ...
J. Thomson +6 more
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2010
Neural stem cells represent a heterogeneous population of mitotically active, self-renewing and multipotent cells of both the developing and the adult central nervous system (CNS) showing complex patterns of gene expression that may vary in both space and time.
Stefano Pluchino +7 more
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Neural stem cells represent a heterogeneous population of mitotically active, self-renewing and multipotent cells of both the developing and the adult central nervous system (CNS) showing complex patterns of gene expression that may vary in both space and time.
Stefano Pluchino +7 more
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The culture of neural stem cells
Journal of Cellular Biochemistry, 2008AbstractA stem cell has three important features. Firstly, the ability of self‐renewal: making identical copies of itself. Secondly, multipotency, generating all the major cell lineages of the host tissue (in the case of embryonic stem cells—pluripotency). Thirdly, the ability to generate/regenerate tissues.
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Proteomics of neural stem cells
Expert Review of Proteomics, 2008The isolation of neural stem cells from fetal and adult mammalian CNS and the demonstration of functional neurogenesis in adult CNS have offered perspectives for treatment of many devastating hereditary and acquired neurological diseases. Due to this enormous potential, neural stem cells are a subject of extensive molecular profiling studies with a ...
Hana Kovarova +3 more
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Neural stem cells and cell death
Toxicology Letters, 2004Neural stem cells (NSC) undergo apoptotic cell death as an essential component of neural development. Here, we present the results of our studies on the mechanisms by which NSC undergo cell death in response to neurotoxic insults. As experimental models we used primary culture of adult NSC from the subventricular zone of the rat brain, and the neural ...
E Sleeper +3 more
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The development of neural stem cells
Nature, 2001The discovery of stem cells that can generate neural tissue has raised new possibilities for repairing the nervous system. A rush of papers proclaiming adult stem cell plasticity has fostered the notion that there is essentially one stem cell type that, with the right impetus, can create whatever progeny our heart, liver or other vital organ desires ...
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