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Neural Stem Cells and Their Manipulation
2006Extracellular signals dictate the biological processes of neural stem cells (NSCs) both in vivo and in vitro. The intracellular response elicited by these signals is dependent on the context in which the signal is received, which in turn is decided by previous and concurrent signals impinging on the cell.
Prithi Rajan, Evan Y. Snyder
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Neural Transplantation and Stem Cells
2009Recent results have raised important questions on our ability to amplify stem cell populations in sufficient numbers as to be useful for therapy. Several reports have indicated that human stem cell populations harvested from the adult have low or undetectable telomerase levels, age in culture, and may not be propagated indefinitely.
Mohan C. Vemuri, Mahendra S. Rao
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Neural Stem Cells and Their Plasticity [PDF]
, 2003 Stem cells are functional units in both development and tissue homeostasis and can be found in a variety of embryonic and adult mammalian tissues. These cells are thought to arise from totipotent embryonic stem (ES) cells of the inner cell mass of the blastocyst from which distinct groups of precursors segregate into the three main germ layers ...
Rossella Galli +2 more
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2007
Stem cells are defined by their ability to both self-renew and give rise to multiple lineages in vivo and/or in vitro. As discussed in other chapters in this volume, the embryonic neural crest is a multipotent tissue that gives rise to a plethora of differentiated cell types in the adult organism and is unique to vertebrate embryos.
Patricia A. Labosky, Lu Teng
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Stem cells are defined by their ability to both self-renew and give rise to multiple lineages in vivo and/or in vitro. As discussed in other chapters in this volume, the embryonic neural crest is a multipotent tissue that gives rise to a plethora of differentiated cell types in the adult organism and is unique to vertebrate embryos.
Patricia A. Labosky, Lu Teng
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Science, 2000
Neural stem cells exist not only in the developing mammalian nervous system but also in the adult nervous system of all mammalian organisms, including humans. Neural stem cells can also be derived from more primitive embryonic stem cells. The location of the adult stem cells and the brain regions to which their progeny migrate in order to differentiate
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Neural stem cells exist not only in the developing mammalian nervous system but also in the adult nervous system of all mammalian organisms, including humans. Neural stem cells can also be derived from more primitive embryonic stem cells. The location of the adult stem cells and the brain regions to which their progeny migrate in order to differentiate
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Immunomodulation by neural stem cells
Journal of the Neurological Sciences, 2008Neural (stem) cell transplantation has been proposed as a means of cell replacement therapy. Multipotential neural precursor cells (NPCs) that expand in floating spheres, and are (partially) committed to a glial fate, showed excellent remyelinating properties in a focal, chemically induced demyelinated lesion in the rat spinal cord.
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Neural Induction and Neural Stem Cell Development
Regenerative Medicine, 2006Embryonic stem (ES) cells are a pluripotent and renewable cellular resource with tremendous potential for broad applications in regenerative medicine. Arguably the most important consideration for stem cell-based therapies is the ability to precisely direct the differentiation of stem cells along a preferred cellular lineage.
Lan T.H. Dang, Vincent Tropepe
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Mitochondria as central regulators of neural stem cell fate and cognitive function
Nature Reviews Neuroscience, 2018M. Khacho, Richard Harris, R. Slack
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