Results 91 to 100 of about 1,237,621 (358)

Stem Cells, Neural Progenitors, and Engineered Stem Cells [PDF]

, 2014
Human pluripotent stem cells (hPSCs ) have the unique potential to form every cell type in the body. This potential provides opportunities for generating human progenitors and other differentiated cell types for understanding human development and for use in cell type-specific therapies. Equally important is the ability to engineer stem cells and their
Shilpa Iyer, Raj R. Rao
openaire   +3 more sources

A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct ...
Natalia E. Owen, Zanna J. Voysey, Jonathan A. Holbrook, Maura Malpetti, Clara Le Draoulec, Lennart R. B. Spindler, Anna O. G. Goodman, Alpar S. Lazar, Roger A. Barker   +8 more
wiley   +1 more source

Stem Cells: The Good, the Bad and the Ugly [PDF]

arXiv, 2016
Cancer stem cells are controlled by developmental networks that are often topologically indistinguishable from normal, healthy stem cells. The question is why cancer stem cells can be both phenotypically distinct and have morphological effects so different from normal stem cells.
arxiv  

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Adult neural stem cells: The promise of the future

Neuropsychiatric Disease and Treatment, 2007
Philippe TaupinNational Neuroscience Institute, National University of SingaporeAbstract: Stem cells are self-renewing undifferentiated cells that give rise to multiple types of specialized cells of the body. In the adult, stem cells are multipotents and
Philippe Taupin
doaj  

Replicator Dynamics of of Cancer Stem Cell; Selection in the Presence of Differentiation and Plasticity [PDF]

arXiv, 2014
Stem cells have the potential to produce lineages of non-stem cell populations (differentiated cells) via a ubiquitous hierarchal division scheme. Differentiation of a stem cell into (partially) differentiated cells can happen either symmetrically or asymmetrically. The selection dynamics of a mutant cancer stem cell should be investigated in the light
arxiv  

Pathway Analyses of Inherited Neuropathies Identify Putative Common Mechanisms of Axon Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Inherited neuropathies (IN) are associated with over 100 different genetic mutations presenting with a variety of phenotypes. This complexity suggests multiple pathways may converge onto a limited number of downstream pathways to effect axonal injury.
Christopher R. Cashman, Craig Blackstone, Reza Sadjadi   +2 more
wiley   +1 more source

Emerging strategies for nerve repair and regeneration in ischemic stroke: neural stem cell therapy

Neural Regeneration Research
Ischemic stroke is a major cause of mortality and disability worldwide, with limited treatment options available in clinical practice. The emergence of stem cell therapy has provided new hope to the field of stroke treatment via the restoration of brain ...
Siji Wang, Qianyan He, Yang Qu, Wenjing Yin, Ruoyu Zhao, Xuyutian Wang, Yi Yang, Zhen-Ni Guo   +7 more
doaj   +1 more source

Modeling tumorspheres reveals cancer stem cell niche building and plasticity [PDF]

, 2019
Cancer stem cells have been shown to be critical to the development of a variety of solid cancers. The precise interplay mechanisms between cancer stem cells and the rest of a tissue are still not elucidated. To shed light on the interactions between stem and non-stem cancer cell populations we develop a two-population mathematical model, which is ...
arxiv   +1 more source

Combination Cell Therapy with Mesenchymal Stem Cells and Neural Stem Cells for Brain Stroke in Rats

International Journal of Stem Cells, 2015
Objectives Brain stroke is the second most important events that lead to disability and morbidity these days. Although, stroke is important, there is no treatment for curing this problem.
S. Hosseini, M. Farahmandnia, Z. Razi, Somayeh Delavari, Benafsheh Shakibajahromi, F. S. Sarvestani, S. Kazemi, M. Semsar   +7 more
semanticscholar   +1 more source