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Advances in Experimental Medicine and Biology, 2019
Neural stem cell (NSC) transplantation has provided the basis for the development of potentially powerful new therapeutic cell-based strategies for a broad spectrum of clinical diseases, including stroke, psychiatric illnesses such as fetal alcohol spectrum disorders, and cancer.
Julian P. Tuazon +6 more
semanticscholar +4 more sources
Neural stem cell (NSC) transplantation has provided the basis for the development of potentially powerful new therapeutic cell-based strategies for a broad spectrum of clinical diseases, including stroke, psychiatric illnesses such as fetal alcohol spectrum disorders, and cancer.
Julian P. Tuazon +6 more
semanticscholar +4 more sources
Science, 2000
Neural stem cells exist not only in the developing mammalian nervous system but also in the adult nervous system of all mammalian organisms, including humans. Neural stem cells can also be derived from more primitive embryonic stem cells. The location of
F. Gage
semanticscholar +4 more sources
Neural stem cells exist not only in the developing mammalian nervous system but also in the adult nervous system of all mammalian organisms, including humans. Neural stem cells can also be derived from more primitive embryonic stem cells. The location of
F. Gage
semanticscholar +4 more sources
The development of neural stem cells
Nature, 2001The discovery of stem cells that can generate neural tissue has raised new possibilities for repairing the nervous system. A rush of papers proclaiming adult stem cell plasticity has fostered the notion that there is essentially one stem cell type that, with the right impetus, can create whatever progeny our heart, liver or other vital organ desires ...
S. Temple
semanticscholar +4 more sources
Current Opinion in Neurobiology, 2001
In recent papers on neural stem cells, two areas of progress stand out. First, there has been a substantial growth in the published examples of 'transdifferentiation'. Second, there has been progress, albeit more modest, in studies of repair by neural stem cells following transplantation into animal models of disease.
Price, J, Williams, B P
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In recent papers on neural stem cells, two areas of progress stand out. First, there has been a substantial growth in the published examples of 'transdifferentiation'. Second, there has been progress, albeit more modest, in studies of repair by neural stem cells following transplantation into animal models of disease.
Price, J, Williams, B P
openaire +6 more sources
A latent lineage potential in resident neural stem cells enables spinal cord repair
Science, 2020Spinal cord stem cells Injuries to the mammalian spinal cord do not heal easily. Llorens- Bobadilla et al. studied mouse ependymal cells, which function as stem cells for the spinal cord (see the Perspective by Becker and Becker). Chromatin accessibility
Enric Llorens-Bobadilla +11 more
semanticscholar +1 more source
Nature Biotechnology, 2020
The study of brain development in humans is limited by the lack of tissue samples and suitable in vitro models. Here, we model early human neural tube development using human embryonic stem cells cultured in a microfluidic device.
Pedro Rifes +12 more
semanticscholar +1 more source
The study of brain development in humans is limited by the lack of tissue samples and suitable in vitro models. Here, we model early human neural tube development using human embryonic stem cells cultured in a microfluidic device.
Pedro Rifes +12 more
semanticscholar +1 more source
2011
Neural stem/progenitor cell (NPC) cultures are a tool to study the differentiation of neuronal cells and can be used to model disease conditions in studies investigating the pathological mechanisms affecting the development and cellular plasticity of the central nervous system.
Christoffer Tamm +4 more
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Neural stem/progenitor cell (NPC) cultures are a tool to study the differentiation of neuronal cells and can be used to model disease conditions in studies investigating the pathological mechanisms affecting the development and cellular plasticity of the central nervous system.
Christoffer Tamm +4 more
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Hormesis and neural stem cells
Free Radical Biology and Medicine, 2022This paper provides a detailed identification and assessment of hormetic dose responses in neural stem cells (NSCs) as identified in a number of animal models and human tissues, with particular emphasis on cell proliferation and differentiation. Hormetic dose responses were commonly observed following administration of a number of agents, including ...
Calabrese, Edward J +4 more
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Neural stem cell heterogeneity
Progress in Neurobiology, 2018The ‘identity’ of the neural stem cell (NSC) in the adult mammalian brain has captivated the interest and imagination of scientists since the seminal findings in the 1990s revealing the existence of a unique subset of glial-like cells that fulfill the stem cell criteria of self-renewal and multipotentality.
Joly, Jean-Stéphane, Tropepe, Vincent
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