Results 71 to 80 of about 2,086,777 (260)

Neural synchrony predicts children’s learning of novel words

bioRxiv, 2020
Social interactions have a well-studied influence on early development and language learning. Recent work has begun to investigate the neural mechanisms that underlie shared representations of input, documenting neural synchrony or coupling (measured ...
Elise A. Piazza, Ariella Cohen, Juliana E. Trach, C. Lew‐Williams   +3 more
semanticscholar   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Neurophysiological trajectories in Alzheimer’s disease progression

eLife
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β and misfolded tau proteins causing synaptic dysfunction, and progressive neurodegeneration and cognitive decline.
Kiwamu Kudo, Kamalini G Ranasinghe, Hirofumi Morise, Faatimah Syed, Kensuke Sekihara, Katherine P Rankin, Bruce L Miller, Joel H Kramer, Gil D Rabinovici, Keith Vossel, Heidi E Kirsch, Srikantan S Nagarajan   +11 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Synchrony and subjective experience: the neural correlates of the stream of consciousness.

Trends in Cognitive Sciences
Human subjectivity, our first-person conscious experience of the world, is among the deepest scientific mysteries. This opinion article lays out an approach to examining the neural correlates of subjectivity as it unfolds over time. Subjective experience
Matthew D. Lieberman
semanticscholar   +1 more source

Brain-to-Brain Neural Synchrony During Social Interactions: A Systematic Review on Hyperscanning Studies

Applied Sciences, 2020
The aim of this study was to conduct a comprehensive review on hyperscanning research (measuring brain activity simultaneously from more than two people interacting) using an explicit systematic method, the preferred reporting items for systematic ...
C. Nam, Sanghyun Choo, Jiali Huang, Jiyoung Park   +3 more
semanticscholar   +1 more source

Neural synchrony and the development of cortical networks

Trends in Cognitive Sciences, 2010
Recent data indicate that the synchronisation of oscillatory activity is relevant for the development of cortical circuits as demonstrated by the involvement of neural synchrony in synaptic plasticity and changes in the frequency and synchronisation of neural oscillations during development.
Uhlhaas, Peter J., Roux, Frederic, Rodriguez, Eugenio, Rotarska-Jagiela, Anna, Singer, Wolf   +4 more
openaire   +4 more sources

Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment. Emerging evidence suggests that neurodegenerative proteinopathies, particularly hyperphosphorylated tau (p‐tau) and amyloid‐β (Aβ), may contribute to cognitive dysfunction in people with epilepsy (PWE), even in the absence ...
Syeda Amrah Hashmi, Aleksander Luniewski, Vanessa Smith, Matthew McCord, Jaideep Kapur, Mark Quigg, Catherine Joshua, Ifrah Zawar   +7 more
wiley   +1 more source

Mother–Child Synchrony and Behavioral Problems in Chinese Children: A Preliminary fNIRS‐Hyperscanning Study

Brain and Behavior
Introduction Parent–child synchrony, defined as the coordination of biological and behavioral processes during social interactions, serves as a critical predictor of children's psychological health and behavioral outcomes.
Chao Liu, Xi Liang, Xiaoxu Meng, Nanhua Cheng, Shan Lu, Liu Bai, Bingbing Song, Chunming Lu, Zhengyan Wang   +8 more
doaj   +1 more source