Results 21 to 30 of about 32,363 (291)

Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects

open access: yesDisease Models & Mechanisms, 2019
Encephalocele is a clinically important birth defect that can lead to severe disability in childhood and beyond. The embryonic and early fetal pathogenesis of encephalocele is poorly understood and, although usually classified as a ‘neural tube defect ...
Ana Rolo   +4 more
doaj   +1 more source

Associations of prenatally detected choroid plexus cysts with biochemical risk for congenital disorders

open access: yesStudia Medyczne, 2014
Introduction: C horoid plexus cysts are one of the foetus ultrasonography findings that raise parents’ concerns about their child’s health. Usually cysts are found in an estimated 1% all performed ultrasonographies.
Danielius Serapinas   +2 more
doaj   +1 more source

Neural tube defects: current view on etiology, prenatal prevention, and early diagnosis. A review

open access: yesConsilium Medicum, 2023
A literature review on the etiology, prevention, and early diagnosis of neural tube defects is presented, focusing on the causes and risk factors for these disorders.
Liliyana A. Chugunova   +2 more
doaj   +1 more source

Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development

open access: yeseLife, 2020
An extracellular matrix of Fibronectin adheres the neural tube to the two flanking columns of paraxial mesoderm and is required for normal vertebrate development.
Emilie Guillon   +5 more
doaj   +1 more source

Exploratory spatial data analysis for the identification of risk factors to birth defects

open access: yesBMC Public Health, 2004
Background Birth defects, which are the major cause of infant mortality and a leading cause of disability, refer to "Any anomaly, functional or structural, that presents in infancy or later in life and is caused by events preceding birth, whether ...
Song Xinming   +8 more
doaj   +1 more source

Diastematomyelia: A Case with Familial Aggregation of Neural Tube Defects

open access: yesThe Scientific World Journal, 2004
Intrauterine neural tube defects, meningomyelocele, and diastematomyelia are developmental errors at different stages of the closure of the neural tube.
Nuray Öksüz Kanbur   +5 more
doaj   +1 more source

Pregnancy Wastage Due to Fetal Congenital Malformations

open access: yesGynecology Obstetrics & Reproductive Medicine, 2021
OBJECTIVES: To study the pattern of various congenital anomalies in rural Haryana. STUDY DESIGN: This was a retrospective study conducted over 1 and ½ years (from January 2015 to June 2016) in a tertiary care center in Haryana, India.
Vijayata Sangwan   +4 more
doaj   +1 more source

Double site neural tube defects: report of two cases

open access: yesEgyptian Journal of Neurosurgery
Introduction Multiple-site neural tube defect is a congenital defect at two or more locations along the neural axis. Double-site neural defects are very rare, having a normal segment between two neural tube defects, and are different from complex spinal ...
Jauhar Malik, Nayil Malik
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

A computational dynamic systems model for in silico prediction of neural tube closure defects

open access: yesCurrent Research in Toxicology
Neural tube closure is a critical morphogenetic event during early vertebrate development. This complex process is susceptible to perturbation by genetic errors and chemical disruption, which can induce severe neural tube defects (NTDs) such as spina ...
Job H. Berkhout   +7 more
doaj   +1 more source

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