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Trimethoprim potentiates valproic acid-induced Neural Tube Defects (NTDs) in mice

Reproductive Toxicology, 1993
The antiepileptic drug valproic acid (VPA) may produce NTDs because of interference with folate metabolism. Therefore, the possible interactions of VPA with the dihydrofolate reductase inhibitor trimethoprim (TM) was investigated. The combination of TM with sulfamethoxazol is used for treatment of urinary infections, the most common complications of ...
Elmazar, Mohamed M., Nau, Heinz
openaire   +2 more sources

Flour Fortification and the Prevention of Neural Tube Defects (NTDs)

2019
Neural tube defects (NTDs) are a group of major congenital anomalies resulting from very early disruption in the development of the central nervous system; they include spina bifida, anencephaly, and encephalocele. These conditions are incurable and often incompatible with life, resulting in stillbirths, as well as neonatal, infant, and under-five ...
Beckett, Emma, Lucock, Mark
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Maternal Caffeine Intake, Selected Metabolic Gene Variants, and Neural Tube Defects (NTDs)

Annals of Epidemiology, 2007
Purpose Using data from the National Birth Defects Prevention Study, we examined associations between NTDs and maternal caffeine intake, gene variants for caffeine metabolism, and their joint effects. Methods Total average caffeine per day was summed from maternal interview reports of coffee, tea, soda, and chocolate intake.
R.J. Schmidt   +5 more
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Ethanol potentiates valproic acid-induced neural tube defects (NTDs) in mice due to toxicokinetic interactions

Reproductive Toxicology, 1995
Both the antiepileptic drug valproic acid (VPA) and ethanol interfere with fetal folate metabolism, which may contribute to their mechanism of teratogenesis. Therefore, the possible interaction between VPA and ethanol was investigated in mice. Ethanol (2 x 2.5 g/kg) was given orally 4 and 1 h prior to VPA (300 and 400 mg/kg, SC) in day 8.25 pregnant ...
Elmazar, Mohamed M., Nau, Heinz
openaire   +2 more sources

Genetic studies in neural tube defects. NTD Collaborative Group.

Pediatric neurosurgery, 2000
Neural tube defects (NTD) are one of the most common birth defects and are caused by both environmental and genetic factors. The approach to identifying the genes predisposing to NTD, through linkage analysis and candidate gene analysis, is reviewed along with characteristics of a large, nationally ascertained cohort of families.
E C, Melvin   +23 more
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Embryology Applied to Neural Tube Defects (NTDs)

2008
Spina bifida is a frequent congenital malformation involving the spinal cord. It was first described by Nicolas Tulp in 1651 (Figs. 2.1 and 2.2). Nicolas Tulp is also famous for the portrait Rembrandt painted of him during his anatomical lessons. The term spina bifida was suggested by Tulp and proposed solely to describe the vertebral anomaly that was ...
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The impact of prenatal diagnosis on neural tube defect (NTD) pregnancy versus birth incidence in British Columbia

Journal of Applied Genetics, 2006
The birth incidence of neural tube defect (NTD) cases in British Columbia (B.C.), and elsewhere in North America, is reported to be declining. This decline is being attributed to folic acid (FA) supplementation and food fortification, but 2nd trimester prenatal screening of pregnancies for NTDs and other congenital anomalies has increased during this ...
Margot I, Van Allen   +12 more
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