Influenza hemagglutinin and neuraminidase multivalent vaccine elicits broader protective immune responses compared to vaccine formulations composed of hemagglutinin or neuraminidase. [PDF]
Hum Vaccin ImmunotherUno N, Ross TM.
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Epidemiological and Genetic Characterization of Three H9N2 Viruses Causing Human Infections - Changsha City, Hunan Province, China, April 2025. [PDF]
China CDC WklyHuang C +8 more
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Low levels of influenza H5N1 HA and NA antibodies in the human population are boosted by seasonal H1N1 infection but not by H3N2 infection or influenza vaccination. [PDF]
mBioWerner AP +7 more
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Determination of Hemagglutinin and Neuraminidase Genetic Variation of Human Influenza A(H1N1)pdm09 Virus Strain Isolated From Deceased Patients in Shiraz, Iran: A Cross-Sectional Study. [PDF]
Health Sci RepBarkhori R +5 more
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Influenza vaccine strain selection is informed by international efforts to track antigenic change, focusing on the viral hemagglutinin protein. Recent research advocates monitoring neuraminidase for immune escape mutations that could reduce vaccine efficacy.
Annette, Fox, Louise, Carolan
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Two neuraminidase activities have been found in normal human liver, one soluble and the other particulate and essentially bound to the lysosomes. With storage of the liver at −80°C, no loss of either type of activity was noted for up to a year. KCl extracts of the soluble enzyme were stable for 15 days when stored in liquid nitrogen. For the sediments (
D M, Meyer, M, Lemonnier, R, Bourrillon
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Mutations of neuraminidase implicated in neuraminidase inhibitors resistance
Journal of Clinical Virology, 2008Influenza constitutes one of the most important upper respiratory tract infections regarding morbidity, and mortality. Prevention and treatment of influenza rely on inactivated vaccines and antiviral drugs. Zanamivir and Oseltamivir, the currently available influenza neuraminidase inhibitors (NAI) can be used in clinical practice for the treatment of ...
Olivier, Ferraris, Bruno, Lina
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Neuraminidase Gangliosides Interactions
1978Gangliosides are sialoglycolipids containing one hydrophilic (the acidic oligosaccharide) and one hydrophobic (the N-acylsphingosine) portion. Due to this chemical property they behave, in water, as soluble amphiphilic compounds and occur as free molecules (monomers), below a certain concentration, and as aggregates (micelles) over that concentration ...
G, Tettamanti +3 more
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