Results 171 to 180 of about 87,065 (293)

Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a clinically and biologically heterogeneous neurodegenerative disorder, driven by multiple mechanisms among which are lysosomal and mitochondrial dysfunction. Here, we explored blood‐based lysosomal and mitochondrial profiles in relation to PD diagnosis and severity.
Janna van Wetering, Manon M. van Ingen, Evelien Timmermans, Sjors G.J.G. in't Veld, Henk W. Berendse, Charlotte E. Teunissen, Wilma D.J. van de Berg   +6 more
wiley   +1 more source

Estetrol Enhances Mitochondrial Bioenergetics and Neurite Outgrowth in Cellular Models of Alzheimer's Disease. [PDF]

Cells
Grimm A, Riou A, Gaillard C, Broeglin A, Ureshino RP, Dion V, Gérard C, Eckert A.   +7 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Discovery of VU6077564: A Selective M₁ Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons. [PDF]

ACS Chem Neurosci
Berida TI, Dodd CJ, Wilkinson JC, Smith DR, Chang S, Presley CC, Peng L, Sant S, Krishnan S, Zagol-Ikapitte I, Watson KJ, Thompson Gray A, Rodriguez AL, Cho HP, Jones CK, Boutaud O, Niswender CM, Engers DW, Fernyhough P, Lindsley CW, Childress ES.   +20 more
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

S-equol Modulates T3-Induced Transcription and Neurite Outgrowth in Neuronal Cells. [PDF]

Int J Mol Sci
Fujiwara Y, Ariyani W, Ninomiya A, Miyazaki W, Ota R, Amano I, Koibuchi N.   +6 more
europepmc   +1 more source

The Histidine 382 Residue Influences the Thermal Stability and Binding Propensity of the E2 Domain of Amyloid Precursor Protein

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The E2 domain of amyloid precursor protein (APP_E2) plays a central role in the protein's function. We reinvestigate how the missense mutation, ΔH382L, affects the domain's thermal stability and ligand binding propensity through differential scanning fluorometry.
Sphamandla Ndlovu, Candice Ngubane, Zamaxasibe Nxele, Raymond Hewer, Alexandré Delport   +4 more
wiley   +1 more source

AAV-Driven miR-146a Promotes Neurite Outgrowth and Axonal Regeneration in Cortical Neurons. [PDF]

J Neurochem
Matos VUS, Almeida RA, Ferreira CG, Alves MTR, Braga MP, Silva MC, da Silva TF, Guimarães PPG, Soriani FM, Caramelli P, Costa MR, Michel U, Ribas VT.   +12 more
europepmc   +1 more source

Engineering In Vitro Models of Skeletal Muscle With Neuromuscular Junctions Using Hierarchical Micro‐Nano Biomaterials: Cooperative Effect of Adhesion Ligand Nanoclustering and Surface Anisotropy

Small, EarlyView.
This study investigates the cooperative effects of adhesive ligand distribution, density, and biomaterial morphology for innervated skeletal muscle tissue engineering. Ligand nanoclusters were created in aligned micropatterns by electrospinning of a RAFT‐synthesized polymer with controlled ligand presentation.
Shirin Nour, Kristy Swiderski, Sahar Salehi, Gordon S. Lynch, Andrea J. O'Connor, Greg G. Qiao, Daniel E. Heath   +6 more
wiley   +1 more source

GPR88 promotes neurite outgrowth of sensory neurons via activation of G_i/o. [PDF]

Front Pharmacol
Ün D, Gilbert C, Steinkellner T, Salzer I, Freissmuth M.   +4 more
europepmc   +1 more source