Results 121 to 130 of about 658,405 (249)

Inhibition of Abnormal Elevated α‐Synuclein Ameliorates Dopaminergic Neuron Degeneration in Parkinson's Disease Mouse Model

Aging Cell, Volume 25, Issue 10, October 2026.
α‐Syn‐HDOs protect dopaminergic neurons by enhancing BDNF–TrkB signaling through the inhibition of abnormally elevated α‐Syn. These findings position α‐Syn‐HDOs as promising therapeutic candidates for PD and suggest that BDNF may serve as a potential diagnostic biomarker or indicator of treatment efficacy.
Xuenan Wang, Yiru Ding, Lujuan He, Xizhi Kang, Xiwen Geng, Fumika Sakaue, Takanori Yokota, Liang‐wen Zhang, Wei Yao, Ji‐chun Zhang   +9 more
wiley   +1 more source

TGF‐β1 Directly Sensitizes Capsaicin‐Sensitive Lung Vagal Neurons to Promote Airway Hypersensitivity

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Transforming growth factor‐β1 (TGF‐β1) is a pleiotropic cytokine implicated in the pathogenesis of inflammatory airway diseases such as asthma. Airway hypersensitivity (AHS), arising from sensitization of capsaicin‐sensitive lung vagal (CSLV) afferents, is a hallmark of these airway diseases.
Yueh‐Yin Chen, Nai‐Ju Chan, Chun‐Chun Hsu   +2 more
wiley   +1 more source

IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence

Clinical Obesity, Volume 16, Issue 5, October 2026.
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente, Erica L. T. van den Akker, Metin Cetiner, Karine Clément, Elizabeth Forsythe, Alastair Garfield, Peter Kühnen, Gabriel Ángel Martos‐Moreno, David Meeker, Hermann L. Müller, Hanneke M. van Santen, Julia von Schnurbein, Bérénice Segrestin, Tomohiro Tanaka, Manuel Tena‐Sempere, Martin Wabitsch, Stefanie Zorn, I. Sadaf Farooqi   +17 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, Volume 15, Issue 36, 25 September 2026.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

James Corbett Memoriam

James Corbett was known for his pioneering work studying idiopathic intracranial hypertension. He dedicated his research to this topic throughout his career.
North American Neuro-Ophthalmology Society
core  

Examining referral patterns to neuro-ophthalmologists

, 2019
Neuro-ophthalmologists specialize in complex, urgent, vision- and life-threatening problems, diagnostic dilemmas, and management of complex work-ups. Access is currently limited by a relatively small number of neuro-ophthalmologists, and patients may be ...
Leanne D. Stunkel; Devin Mackay; Beau Bruce; Nancy J. Newman; Valerie Biousse
core  

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Isolated dysphagia masking myasthenia gravis diagnosis. [PDF]

Arq Neuropsiquiatr
Lusvarghi IL, Bernis EH, Lopes RG, Vieira RC, Fernandes BFS, Queiroz DTU.   +5 more
europepmc   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, Volume 13, Issue 53, 24 September 2026.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Modeling ALS in a dish: how organoids are transforming research. [PDF]

Front Med (Lausanne)
Galluzzi G, Ruocco G, Fornetti E, Genovese I.   +3 more
europepmc   +1 more source